Jason M. Shapiro, MD
Jason Shapiro, MD
Assistant Professor of Medicine
E-mail: [email protected]
My goal is to determine the factors associated with favorable outcomes of childhood inflammatory bowel disease (IBD). IBD is a chronic, debilitating condition characterized by relapsing and remitting episodes of gastrointestinal inflammation. Pathogenesis has been attributed to a combination of causative factors including genetic predisposition, alterations in the gut microbiome, defects in the innate and adaptive immune system and various putative environmental exposures. The incidence of IBD in children has inexplicably increased over the past few decades and despite new therapies, little is known about how to optimize these treatments to achieve the best long-term outcomes. In 2010 I received an NIH T32 Ruth L. Kirschstein National Research Award to complete my last 2 years of pediatric gastroenterology fellowship here at Rhode Island Hospital/Hasbro Children’s Hospital. Under the mentorship of Dr. Jack Wands, my work focused on the identification and characterization of novel biomarkers of colonic dysplasia, a precursor of colon cancer in patients with long standing IBD. My academic focus remains on clinical and translational aspects of inflammatory bowel disease research. I am currently the co-principal investigator of the Ocean State Crohn’s and Colitis Area Registry (OSCCAR) along with the primary principal investigator, Dr. Bruce E. Sands, the Dr. Burrill B. Crohn Professor of Medicine and Chief of the Henry D. Janowitz Division of Gastroenterology at the Icahn School of Medicine at Mount Sinai. A well defined, inception cohort of patients with newly diagnosed IBD in the state of Rhode Island, OSCCAR represents a unique opportunity to study the natural history of IBD over time. In addition, leveraging the clinical, microbial and genomic data obtained from analysis of the various OSCCAR biospecimens represents an exciting opportunity to further define the immunopathogenesis of inflammatory bowel disease.
Shapiro JM, Kerur B. Do Orally Administered Immunoglobulin-Based Agents Represent the Future of IBD Therapeutics? Digestive Diseases and Sciences 2015; epub ahead of print. PMID 26182902.
Shapiro JM, Cho JH, Sands BE, LeLeiko NS. Bridging The Gap Between Host Immune Response and Intestinal Dysbiosis in Inflammatory Bowel Disease: Does Immunoglobulin A Mark the Spot? Clinical Gastroenterology and Hepatology 2015;13(5):842-46. PMID: 25725444.
Townsend P, Zhang Q, Shapiro JM, Webb-Robertson BJ, Bramer L, Schepmoes AA, Weitz KK, Mallette M, Moniz H, Bright R, Kamphaus T, Shah SA, Sands BE, LeLeiko NS. Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study. Inflammatory Bowel Diseases 2015;21(8):1935-41. PMID 26199992.
Krishnarao A, de Leon L, Bright R, Moniz H, Law M, LeLeiko N, Sands BE, Merrick M, Flowers N, Shapiro J, Wallenstein S, Giacalone J, Shah SA. Testing for Clostridium difficile in Patients With Newly Diagnosed Inflammatory Bowel Disease in a Community Setting. Inflammatory Bowel Diseases 2015;21(3):564-9. PMID: 25581825.
Saha S, Zhao YQ, Shah SA, Degli-Esposti SD, Lidofsky S, Shapiro J, Bright R, Law M, Moniz H, Samad Z, Merrick M, Sands B. Body Image Dissatisfaction in Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2015;21(2):345-52. PMID: 25569736.
Reed-Knight B, Lobato D, Hagin S, McQuaid E, Nassau J, Boergers J, Seifer R, Soursa K, Bancroft B, Shapiro J, LeLeiko, N. Depressive Symptoms in Youth with Inflammatory Bowel Disease Compared to a Community Sample. Inflammatory Bowel Diseases 2014;20(4):614-20. PMID: 24518604.
LeLeiko NS, Lobato D, Hagin S, Hayes C, McQuaid EL, Seifer R, Kopel SJ, Boergers J, Nassau J, Soursa K, Shapiro J, Bancroft B. 6-Thioguanine Levels in Pediatric IBD Patients: Adherence is More Important Than Dose. Inflammatory Bowel Diseases 2013; 19(12):2652-8. PMID: 24105391.
LeLeiko N, Lobato D, Hagin S, McQuaid E, Seifer R, Kopel S, Boergers J, Nassau J, Soursa K, Shapiro J, Bancroft B. Rates and Predictors of Oral Medication Adherence in Pediatric IBD Patients. Inflammatory Bowel Diseases 2013; 19(4):832-9. PMID: 23446336.
Shapiro J, LeLeiko, NS. New Guidelines for Diagnosis and Treatment of C difficile. AAP Grand Rounds 2013; 30(5):60.