Brown scientist to play key role in $10M study of cell structure in diseases, disorders and aging

Nicola Neretti to join a new five-year, $10 million research effort funded by the National Institutes of Health to investigate how changes in cell structure can affect health and disease. 

PROVIDENCE, R.I. [Brown University] — A new five-year, $10 million grant from the National Institutes of Health will enable Brown scholar and molecular biologist Nicola Neretti to serve as co-investigator for a multi-institution research center studying how cell structures affect functions in health and disease.

Brown researchers uncover novel mechanisms of osteoarthritis

The study of human aging has advanced considerably over the years, yielding new discoveries and methods for how we can mitigate the negative effects of natural aging over the course of one’s life. We now know that aging proceeds through only a handful of evolutionarily conserved biological processes that lead to changes in cellular and organ function, promoting a wide array of age-associated diseases, loss of resilience, frailty and ultimately death. Due to the many sources that ultimately can contribute to aging, interdisciplinary research approaches are becoming more popular, often focusing on a specific component of aging that can be applied to broader mechanisms of aging. The researchers at Brown’s Center on the Biology of Aging have adopted this approach and have made significant breakthroughs since the foundation of the Center.

Marco DeCecco of the Sedivy Lab Published in Nature

Marco DeCecco's article "L1 drives IFN in senescent cells and promotes age-associated inflammation" has been published in the journal Nature.  See the full article here:, and read the lab's write-up in the Providence Journal here: