Description
Bioinformatics is important to ensure computationally efficient and informative genomic and genetic data analyses. CBLCC provides comprehensive bioinformatics support, from experimental design to data analysis, including Next Generation Sequencing (NGS) studies. The data analysis includes, but not limited to, DNA- and RNA-Seq, CHIP-Seq and single cell RNA-Seq. In addition to data analysis, genomic data visualization and comparative network biology applications extensively included to support research projects. CBLCC can also provide guidance with large consortia data such as from The Cancer Genomic Atlas (TCGA), 1000 genomes and ENCODE or assistance for webservers such as cBioPortal, gnomAD, HPA (Human Protein Atlas). Cancer Bioinformatics also provides opportunity to develop novel tools in cutting edge cancer research at Legorreta Cancer Center. CBLCC will continuously evaluate and update bioinformatics applications to maintain best practices for designing custom computational biology and bioinformatics pipelines from data pre-processing to variant discovery. Cancer Bioinformatics will also support and provide education in computational biology and bioinformatics from cancer biology perspectives.
Goals
Collaborate with and support translational clinical and research teams in the design of experiments and analysis of genomic datasets. Develop experimental designs with integration of bioinformatics for intervention, and observational studies. Conduct downstream bioinformatics analysis including pathway, differential gene expression, and network biology analysis and interpret the results. Process raw genomic data (e.g., RNA-seq, exome sequencing) and provide genomic data visualization and annotation. Evaluate and support the bioinformatics efforts in grant proposals and manuscripts in collaboration with investigators. Review new bioinformatics methodology for applicability to cancer research projects. In the case of current methods are inadequate, CBLCC will develop novel bioinformatics tools and methods for specific cancer research projects.
Contact
Director: Alper Uzun, PhD
Legorreta Cancer Center at Brown
Email: [email protected]
More information about "Cancer Bioinformatics Shared Resource (CBSR)" can be found in the link"
Cancer Bioinformatics Shared Resource Poster
