Description

In vivo bioluminescence and fluorescence imaging capabilities including spectral unmixing have been employed in cancer research for over 15 years. The technological advances in instrumentation have accelerated the pace of preclinical cancer biology research and cancer drug testing in immune-deficient, immune-competent and transgenic mouse models. Imaging has enabled visualization of molecular events within tumors as well as incorporation of novel molecular probes of drug action or biological readouts on tumor protease activity or tumor angiogenesis, among others. We have set up in vivo bioluminescence and fluorescence imaging capabilities that have supported studies of tumor development and progression and that have led to numerous publications. Applications include studies of cancer gene effects through gene knockdown or knockout of tumor suppressor genes or overexpression of oncogenes with imaging of effects on tumor growth, tumor angiogenesis, or cancer pathway activation.

Goals

Advise investigators with experimental design for in vivo imaging applications, provide access to instrumentation and training. Assist investigators with in vivo mouse, organ or cellular imaging, probe selection, antibody labeling, image analysis and presentation. Provide support for grant submissions.

Contact

Director: Arunasalam Navaraj, PhD
Research Scientist and Lab Program Director
Joint Program in Cancer Biology
Department of Pathology & Laboratory Medicine
Brown University
Email: [email protected]

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