Children's Environmental Health

Group Leader: Dr. Joseph Braun, Associate Professor of Epidemiology

Current Group Members: Dr. Nan Li, Dr. Samantha Kingsley, Dr. Medina Jackson-Browne, Dr. Clara Sears, Dr. Melissa Eliot, Geetika Kalloo, Julie Skarha

Does exposure to environmental pollutants during fetal development, infancy, or childhood affect the risk of disease and well being across the lifespan? How does exposure to toxic chemicals change over the lifespan and what can people do to reduce their exposure?

 

 

In the Center for Environmental Health and Technology, our team is answering these questions using several studies from the United States and Canada. These studies (i.e., prospective cohort studies) have enrolled women in early pregnancy (or before pregnancy in some cases) and followed them and their children over time. We have specifically been trying to address questions regarding the patterns, determinants, biological pathways, and health effects of environmental chemical exposures.

Our group is enumerating the sources and determinants of chemical exposures in pregnant women and children so that individuals can modify their behavior to reduce exposure or so that policy makers can identify exposure sources that are amenable to regulatory interventions. In addition, our work has helped to quantify the role of exposure measurement error in studies of non-persistent environmental chemical exposures.

  • Braun JM, Kalkbrenner AE, Calafat AM, et al.  Variability and Predictors of Urinary Bisphenol A Concentrations During Pregnancy.  Environmental Health Perspectives. 2011;119(1):131-7.
  • Stacy SL, Eliot M, Calafat AM, Chen A, Lanphear B, Hauser R, Papandonatos GD, Sathyanarayana S, Ye X, Yolton K, Braun J. Patterns, Variability, and Predictors of Urinary Bisphenol A Concentrations during Childhood. Environmental Science & Technology. 2016.

We have conducted numerous studies quantifying the role of environmental chemicals in the etiology of birth weight, body composition, early childhood growth, breastfeeding duration, and childhood obesity, all known risk factor for cardiometabolic dysfunction. We use sophisticated statistical methods to identify potential periods of heightened susceptibility to chemical exposures.

  • Braun JM, Romano ME, Webster G, Calafat AM, Chen A, Yolton K, and Lanphear BP. Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study. Obesity. 2016; 24: 231-7.
  • Shoaff J, Papandonatos GD, Calafat AM, Ye X, Chen A, Lanphear BP, Yolton K, Braun JM. Early-Life Phthalate Exposure and Adiposity at 8 Years of Age. Environmental Health Perspectives. 2017;125(9):097008. doi: 10.1289/EHP1022.

Our team has been identifying chemical risk factors for several childhood neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and learning disabilities. We examine a wide range of potential neurotoxicants, including lead, triclosan, phthalates, and bisphenol A.

  • Braun JM, Kahn RS, Froehlich T, et al. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environmental Health Perspectives 2006;114:1904-9.
  • Braun JM, Kalkbrenner AE, Just AC, et al. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study. Environmental Health Perspectives 2014;122:513-20.

Humans are exposed to hundreds of environmental chemicals as a mixture across the lifespan and we have limited understanding of their effects on human health. We developed a framework to characterize questions that epidemiological studies can address regarding chemical mixtures and implemented several different methods to assess the individual and cumulative effect of chemical mixtures on children’s health.

  • Braun JM, Gennings C, Hauser R, Webster TF. What Can Epidemiological Studies Tell Us about the Impact of Chemical Mixtures on Human Health? Environmental Health Perspectives. 2016;124(1):A6-9.
  • Romano ME, Eliot MN, Zoeller RT, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Chen A, Lanphear BP, Braun JM. Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: The HOME Study. International Journal of Hygiene and Environmental Health. 2018.

We use molecular epidemiology approaches to probe specific biological pathways or identify novel biological pathways that chemical exposures act upon. This includes endocrine pathways like thyroid and adrenal function, as well as DNA methylation and metabolomics. Our group was the first to examine the relation between prenatal perfluoroalkyl substance exposure and leukocyte DNA methylation at >450,000 CpG loci.

  • Braun JM, Chen A, Hoofnagle A, Papandonatos GD, Jackson-Browne M, Hauser R, Romano ME, Karagas MR, Yolton K, Thomas Zoeller R, Lanphear BP. Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels. Hormones and Behavior. 2017.
  • Kingsley SL, Kelsey KT, Butler R, Chen A, Eliot MN, Romano ME, Houseman A, Koestler DC, Lanphear BP, Yolton K, Braun JM. Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study. Environmental Research. 2017;158:174-8.