We are modernizing toxicity and drug testing by measuring and integrating the biologic responses of miniaturized human tissues.
There is a large and growing number of potential toxicants and drugs whose concentration-dependent effects are unknown. Current animal and simple 2D cell culture models do not rapidly and effectively identify human health risks. Needed are new, cost-effective, and predictive assays that can assess adverse effects.
Through an integration of biology and engineering, we have devised simple, high-throughput 3D microtissues as predictive biology platforms that reflect human physiology and disease, solving fundamental questions of adverse biological response. We use quantitative confocal imaging of 3D human microtissues to identify pathologic responses to chemical and drug exposures.
The Center to Advance Predictive Biology provides a scholarly environment for research and teaching in the development and use of state-of-the-art humane approaches to understanding the fundamental characteristics of health and disease, including identifying alternatives to animal testing for screen of environmental toxicants and new drugs.
We are interested in collaborating with industry to accelerate the Center's mission and research and development programs. Types of support include general support for the Center, sponsored research, and collaboration around areas of mutual interest.
Our strategy is to optimize and validate in vitro assays using human 3D microtissues visualized by high-throughput/high-content imaging. These novel platforms for predictive biology are designed to address the unmet need for screening and safety assessment of large numbers of environmental chemicals and emerging toxicants, thus protecting human health and the environment.
This center is supported through grants from the National Institute of Environmental Health Sciences and a generous gift by Donna McGraw Weiss (’89) and Jason Weiss.