Home > Guest Lectures > The Genome and the Computational Sciences: The Next Paradigms

The Genome and the Computational Sciences: The Next Paradigms

Brown University,
The Center for Computational Molecular Biology, and
The Department of Computer Science

Present a Three-Day Symposium

The Genome and the Computational Sciences:
The Next Paradigms

December 6-8, 2006
3rd floor, CIT
115 Waterman Street, Providence, RI 02912

This premier event brings together, in the post-genome-sequence phase of genomics, influential entrepreneurs, leaders, and visionaries from academia and industry who will build the next paradigms in genomics and biotechnology. This symposium, marking the inauguration of Brown's Center for Computational Molecular Biology, features 14 Distinguished Lectures. Each lecturer will present provocative, critical, and visionary talks on the state of the art in their academic and technological domains, and discuss the emerging paradigm changes made possible by their research and development work. All sessions will feature lively scientific dialogue and rigorous questioning by participants and audience members, including a post-lecture "sweatbox", a concept borrowed with admiration from the famous Embryology Course at the Marine Biological Laboratory, Woods Hole.

Brown Media Relations: Brown Symposium Highlights Next Wave in Biology and Business

Day 1, December 6: Genomics, Vaccines, and the Brain

12:00-1:00 pm: Lunch

1:00-1:15 pm: Opening Remarks

Sorin Istrail

Symposium Chair, Director, CCMB, Brown University

Eli Upfal

Chair, Computer Science Department, Brown University

Clyde Briant

Vice President for Research, Brown University

1:15-2:00 pm

Leon Cooper: Is Theory Possible in Neuroscience?

Thomas J. Watson, Sr. Professor of Physics, Brown University Professor Cooper received a Nobel Prize for his work on superconductivity. He is Director of the Institute for Brain and Neural Systems.

2:00-2:30 pm: Sweatbox Q&A Session

2:30-3:15 pm

David Barker: Capturing Common Variation in the Human Genome on a Single Microarray

Vice President and Chief Scientific Officer, Illumina
Dr. Barker is CSO of Illumina, a leading company in the HapMap-based genome-wide disease association studies.

3:15-3:45 pm: Sweatbox Q&A Session

3:45-4:00 pm: Break

4:00-4:15 pm: Special Plenary Session: Introduction by Ruth Simmons, President, Brown University

4:15-5:00 pm

J. Craig Venter: Genomics: From Medicine to the Environment

President, J. C. Venter Institute
Dr. Craig Venter is a leading scientist of the 21st century for his visionary contributions in genomic research. In the mid-1980s he developed expressed sequenced tags or ESTs, which enable rapid gene discovery. In 1992, he founded The Institute for Genomic Research (TIGR) where, using his new whole genome shotgun sequencing, he and his team deciphered the genome of the first free living organism, Haemophilus influenzae. Later, as head of Celera Genomics, he used the technique to decode the human, drosophila, mouse, and rat genomes. Dr. Venter and his teams continue to blaze new trails in mammalian, microbial, plant, viral, environmental, and synthetic genomics.

5:00-5:30 pm: Sweatbox Q&A Session

5:30-6:15 pm

Stephen Hoffman: The Journey from Genomics, Molecular Immunology and DNA Vaccines to an Attenuated Whole Parasite Malaria Vaccine

CEO and CSO, Sanaria
Dr. Hoffman, world-renowned for his work on malaria, founded Sanaria to develop an extremely promising malaria vaccine. He was Senior VP for Biologics at Celera Genomics, has done extensive fieldwork all over the world on such diseases as typhoid fever, malaria, lymphatic dwelling filariasis, cholera, and dengue, and is a member of the Institute of Medicine of the National Academies.

6:15-6:45 pm: Sweatbox Q&A Session

6:45-7:45 pm: Reception hosted by Provost David Kertzer

Day 2, December 7: Biomolecular Simulations, DNA, and Proteins

8:30-9:00 am: Continental Breakfast

9:00-9:45 am

Jeffrey Skolnick: Prediction of Protein Structure, Function and Druggability on a Proteomic Scale

Professor, Director, Center for the Study of Systems Biology, Georgia Tech
Dr. Skolnick is renowned for his work on protein folding and is one of the most successful protein-folding predictors at the international CASP protein-folding competition.

9:45-10:15 am: Sweatbox Q&A Session

10:15-11:00 am

Jonathan King: Why Deciphering the Amino Acid Sequence Rules for Protein Folding is So Difficult: The Case of the Beta-Sheet Fold

Professor of Molecular Biology, MIT
Dr. King is renowned for his work on genes and proteins of microorganisms, virus self-assembly and protein misfolding. He was a founder of the Council for Responsible Genetics and Co-Chair of its Committee on the Military Use of Biological Research.

11:00-11:30 am: Sweatbox Q&A Session

12:00-1:00 pm: Lunch

1:00-1:15 pm

Special Plenary Session: Introduction by Clyde Briant, Vice President for Research, Brown University

1:15-2:00 pm

David E. Shaw: New Architectures for a New Biology

Chief Scientist, D. E. Shaw Research
Dr. Shaw is the chief scientist of D. E. Shaw Research and a senior research fellow at the Center for Computational Biology and Bioinformatics at Columbia University. He and his research group are currently involved in the design of massively parallel machine architectures and algorithms for high-speed molecular dynamics simulations, and in the use of such simulations to study biomolecular systems of interest from both a scientific and a pharmaceutical perspective.

2:00-2:30 pm: Sweatbox Q&A Session

2:30-3:15 pm

Eric Kronstadt: Tools of the Trade: The Next Generation of Supercomputers

Director, Deep Computing Institute, IBM
Dr. Kronstadt, Brown '67, is an authority on supercomputing and high-performance computing. The Deep Computing Institute at IBM includes the BlueGene Supercomputer Division and the Computational Biology Center.

3:15-3:45 pm: Sweatbox Q&A Session

4:00-5:00 pm: Introductory Remarks by Rajiv Vohra, Dean of the Faculty - 10th Anniversary Celebration Undergraduate Computational Biology Program

5:15-6:00 pm

Pavel A. Pevzner: The Third Rebuttal of the Random Breakage Theory

Howard Hughes Medical Institute Professor, Ronald R. Taylor Professor of Computer Science, University of California - San Diego
Dr. Pevzner is a pioneer of computational biology and bioinformatics, a co-founder of the RECOMB conference, the top annual conference in the area, and author of two highly influential textbooks.

6:00-6:30 pm: Sweatbox Q&A Session

Wrap-Up Session

Day 3, December 8: Genetics and Medicine

8:30-9:00 am: Continental Breakfast

9:00-9:15 am: Opening Remarks

Eli Adashi

Dean of Medicine and Biological Sciences, Brown University

9:15-10:00 am

Jonathan W. Yewdell: Gained in Translation: The Immunoribosome Hypothesis of Immunosurveillance

Chief, Biology Section National Institute of Allergy and Infectious Diseases, National Institutes of Health
Dr. Yewdell, a world-renowned immunologist, was involved in the first mapping of the influenza virus with monoclonal antibodies, the initial description of immunodominance and ER trafficking and the ability of viral proteins to block antigen presentation, and the 11th influenza A virus.

10:00-10:30 am: Sweatbox Q&A Session

10:30-11:15 am

Jeremy Smith: Dynamics of Protein Binding, Reaction, and Structural Change

Director, the Center for Molecular Biophysics, Oak Ridge National Laboratory
Dr. Smith is a leading scientist in high-performance biomolecular simulations and neuron scattering. He led the biomolecular simulation group at the French Atomic Energy Commission and at the University of Heidelberg and is well known for his work in high-performance computer simulations and neutron scattering experiments on protein dynamics.

11:15-11:45 am: Sweatbox Q&A Session

12:00-1:00 pm: Lunch

1:00-1:45 pm

Christopher Johnson: Computational Bioimaging and Visualization: Challenges and Opportunities

Distinguished Professor and Director, Scientific Computing and Imaging Institute, University of Utah
One of the most influential computer scientists in high-performance visualization and imaging, Dr. Johnson received a NSF Presidential Faculty Fellow award from President Clinton and is a Fellow of the AAAS.

1:45-2:15 pm: Sweatbox Q&A Session

2:30-3:15 pm

David Altshuler: Human Genome Sequence Variation and the Inherited Basis of Disease

Professor, Harvard Medical School and Broad Institute of MIT and Harvard
Dr. Altshuler is one of the top scientists of the international HapMap consortium, the public-private partnership that created the genome-wide maps of human genetic diversity that now guide the design and interpretation of genetic association studies. He is the founding director of the Program in Medical and Population Genetics at the Broad Institute of Harvard and MIT.

3:15-3:45 pm: Sweatbox Q&A Session