1240 [CRN: 23762]Examines the chemical, mechanistic, and structural basis for enzymatic catalysis. Uses examples from the recent literature to examine how the experimental and conceptual tools of chemical synthesis, isotopic labeling, stereochemistry, enzymology, kinetics, and protein structure can be brought to bear to unravel the chemical and physical principles underlying the enormous catalytic acceleration and exquisite structural specificity of enzyme-catalyzed reactions. Prerequisites: Strong background in organic chemistry (CHEM 0350-0360, A or B performance preferable) plus at least one semester of Biochemistry (BIOL 0280, BIOL 1270). Enrollment limited to: 25 students, written permission required.
If enrollments exceed the limit of 25 students, permission to enroll for students who meet the course prerequisites will be allotted in the order: a) first year Chemistry graduate students, b) undergraduate senior concentrators in Chemistry, Biochemistry or Chemical Biology, c) junior concentrators in Chemistry, Biochemistry or Chemical Biology, d) other students. Students who have permission to enroll must attend the first three classes or risk losing their places to someone on the Course waiting list.
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