Lithium enolates are the most widely utilized reactive intermediate in organic synthesis. Prof. Paul Williard and his group have been characterizing these unstable intermediates by crystallizing them and determining their structure by x-ray diffraction analysis and by NMR. Recently the results of this research have been published in the Journal of the American Chemical Society and have been featured on the cover as well as highlighted as a “spotlight” article. See the article in JACS, 2015, 137 (23), 7251, 7247-7356.
Congratulations to the article authors, including Prof. Williard, graduate student Jie Guang, and NMR specialist Dr. Russ Hopson.