Amit Basu

Associate Professor of Chemistry

Research Area

Contact Info

GeoChem 445401-863-9897EmailResearchers@Brown Profile

Research Statement

Our group is interested in questions that lie at the interface of chemistry, biology, and materials science. Research in the group includes: glycochemistry and glycobiology; synthesis and application of novel polymers and nanomaterials; development of new sensors and diagnostic agents. Current foci include the glycochemistry of the plant cell wall and the development of small molecules that interfere with bacterial cell wall dynamics and can serve as leads for new antibiotics.

Areas of Interest

  • Glycobiology
  • Polymers
  • Green chemistry
  • Synthetic organic chemistry
  • Interfacial recognition
  • Nanomaterials

Education

  • 1996 - Ph.D.: University of Illinois at Urbana-Champaign
  • 1992 - B.A.: Reed College

Selected Publications

  • Nayyab, S.; O'Connor, M.; Brewster, J.; Gravier, J.; Jamieson, M.; Magno, E.; Miller, R. D.; Phelan, D.; Roohani, K.; Williard, P.; Basu, A.; Reid, C. W., Diamide Inhibitors of the Bacillus subtilis N-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity. Acs Infect Dis 2017, 3 (6), 421-427.
  • Kuhn, H.; Gutelius, D.; Black, E.; Nadolny, C.; Basu, A.; Reid, C., Anti-bacterial glycosyl triazoles - identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus. Medchemcomm 2014, 5 (8), 1213-1217.
  • Hartman, E.; Levy, C.; Kern, D. M.; Johnson, M. A.; Basu, A., A rapid, inexpensive, and semi-quantitative method for determining pollen tube extension using fluorescence. Plant Methods 2014, 10.
  • Drager, M.; Basu, A., Galactan synthesis in a single step via oligomerization of monosaccharides. Beilstein J Org Chem 2014, 10, 2658-2663.
  • Okoth, R.; Basu, A., End-labeled amino terminated monotelechelic glycopolymers generated by ROMP and Cu(I)-catalyzed azide-alkyne cycloaddition. Beilstein J Org Chem 2013, 9, 608-612.
  • Zhao, J. S.; Liu, Y. F.; Park, H. J.; Boggs, J. M.; Basu, A., Carbohydrate-Coated Fluorescent Silica Nanoparticles as Probes for the Galactose/3-Sulfogalactose Carbohydrate-Carbohydrate Interaction Using Model Systems and Cellular Binding Studies. Bioconjugate Chemistry 2012, 23 (6), 1166-1173.
  • Wang, Y. Q.; Gildersleeve, J. C.; Basu, A.; Zimmt, M. B., Photo- and Biophysical Studies of Lectin-Conjugated Fluorescent Nanoparticles Reduced Sensitivity in High Density Assays. J Phys Chem B 2010, 114 (45), 14487-14494.
  • Seah, N.; Santacroce, P. V.; Basu, A., Probing the Lactose center dot GM3 Carbohydrate-Carbohydrate Interaction with Glycodendrimers. Organic Letters 2009, 11 (3), 559-562.
  • Liu, X.; Basu, A., Core Functionalization of Hollow Polymer Nanocapsules. J Am Chem Soc 2009, 131 (16), 5718-+.
  • Liu, X.; Basu, A., Cross-linked polynorbornene-coated gold nanoparticles: Dependence of particle stability on cross-linking position and cross-linker structure. Langmuir 2008, 24 (19), 11169-11174.
  • Limapichat, W.; Basu, A., Reagentless functionalization of gold nanoparticles via a 3 + 2 Huisgen cycloaddition. Journal of Colloid and Interface Science 2008, 318 (1), 140-144.