"Mutational Analysis of Single Neurons Using Whole-Genome Sequencing"

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Tuesday, April 26, 2016 4:00pm - 5:00pm
Watson CIT - SWIG Boardroom (CIT241)

Peter Park
Associate Professor of Biomedical Informatics
Harvard Medical School 

"Mutational Analysis of Single Neurons Using Whole-Genome Sequencing"

Whole-genome sequencing allows detailed characterization of the mutational landscape in a genome, including single nucleotide, copy number, and structural variants. We will describe our recent work in high-coverage whole-genome sequencing of single neurons to identify somatic mutations in the human brain. Our analysis found somatic retrotransposition events as well as more than a thousand somatic single nucleotide variants per cell, with characteristics different from those of germline and cancer mutations. These somatic mutations allow us to infer nested lineage trees of single neurons, revealing a polyclonal architecture of the human cerebral cortex. 

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