Dr. Ani Eloyan, Assistant Professor in the Department of Biostatistics at Brown University, was recently awarded an NIH R21 grant entitled “Spatiotemporal Modeling of MRI Brain Lesion Trajectories of Biomarker Discovery". Dr. Eloyan will work in collaboration with Dr. Russell Shinohara (co-PI) at the University of Pennsylvania.
This work will develop statistical methods for the analysis of longitudinal magnetic resonance imaging (MRI) data for patients with multiple sclerosis (MS). Disease biomarkers identified from MRI are necessary for studying disease progression in observational studies and for assessing treatment effects of therapies in clinical trials. The proposed statistical methods will be used for the analysis of longitudinal MRI intensity time courses that integrate information across multiple modalities by harnessing the complex data structure of clinical MRI for identifying biomarkers that can be utilized in future studies and that are implementable in MS centers across the country.
Dr. Eloyan joined the Department’s faculty in July 2015 and has deep expertise in high-dimensional data and brain imaging and neuroscience research. Prior to coming to Brown, Dr. Eloyan was an Assistant Professor of Biostatistics at Johns Hopkins, a post she held following her post-doctoral fellowship in that department. Dr. Eloyan's research interests include semi-parametric likelihood based methods for matrix decompositions, statistical analyses of brain images, and integration of various types of complex data structures for analyzing health care data.
Dr. Shinohara’s methodological research spans several concentrations, including causal inference, survival analysis, imaging and large data sets, and general inference problems. He is interested in describing complex processes and studying questions that have direct impacts on human health through clinical trials and observational studies. His collaborative interests are broad in medicine and public health, with particular experience in geriatrics, neurology, and radiology.