Targeting the p38/Snail/PD-L1 axis in Hormone-Therapy Resistance and Metastasis

The proposed work is to develop technology for both civil and military application. This subcontract involves providing expertise in developing statistical methodology. Key tasks to be performed by Dr. Crawford on this project include: (1) developing a scalable and quantitative experimental design to identify the mechanisms underlying hormone therapy resistance and the subsequent molecular responses to p38α and/or PD-L1 inhibition in metastatic castration-resistant prostate cancer (mCRPC); and (2) using computational tools to generate testable hypotheses and identify potentially novel immunologic biomarkers that help overcome hormone therapy resistance.​

Lorin Crawford Staff 1 Research Assistant i

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