Community Engagement

Evolution and Interpretation of Cancer Genomes

April 7, 2017
SWIG Boardroom (CIT241)
Ben Raphael
Professor of Department of Computer Science, Princeton University


Cancer is an evolutionary process driven by somatic mutations that accumulate in a population of cells that form a tumor.  In the past few years, high-throughput DNA sequencing technologies have enabled the measurement of these mutations across thousands of individual tumors.  Despite this wealth of data, our understanding of the cancer mutational landscape remains incomplete. I will describe computational approaches to address key analytical challenges in translating measurements of somatic mutations into deeper insights about the processes that drive cancer development.


Ben Raphael is a Professor of Computer Science at Princeton University.  He received his Ph.D. in Mathematics from University of California, San Diego, and then began research in computational biology and bioinformatics as a postdoctoral fellow.  From 2006-2016, he was an Assistant and Associate Professor of Computer Science at Brown University, and from 2013-2016 was also the Director of the Center for Computational Molecular Biology (CCMB).