Community Engagement

Evolution and Interpretation of Cancer Genomes

April 7, 2017
12:00pm
SWIG Boardroom (CIT241)
Ben Raphael
Professor of Department of Computer Science, Princeton University

Abstract: 

Cancer is an evolutionary process driven by somatic mutations that accumulate in a population of cells that form a tumor.  In the past few years, high-throughput DNA sequencing technologies have enabled the measurement of these mutations across thousands of individual tumors.  Despite this wealth of data, our understanding of the cancer mutational landscape remains incomplete. I will describe computational approaches to address key analytical challenges in translating measurements of somatic mutations into deeper insights about the processes that drive cancer development.

Bio: 

Ben Raphael is a Professor of Computer Science at Princeton University.  He received his Ph.D. in Mathematics from University of California, San Diego, and then began research in computational biology and bioinformatics as a postdoctoral fellow.  From 2006-2016, he was an Assistant and Associate Professor of Computer Science at Brown University, and from 2013-2016 was also the Director of the Center for Computational Molecular Biology (CCMB).