Nanoscale Plasmonic Interferometers for Multispectral, High-Throughput Biochemical Sensing

Nanoscale Plasmonic Interferometers for Multispectral, High-Throughput Biochemical Sensing
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Feng, J, Siu VS, Roelke A, Mehta V, Rhieu SY, Palmore TGR, Pacifici D.  2012.  Nanoscale Plasmonic Interferometers for Multispectral, High-Throughput Biochemical Sensing. Nano Letters. 12(2):602-609.

TitleNanoscale Plasmonic Interferometers for Multispectral, High-Throughput Biochemical Sensing
Publication TypeJournal Article
Year of Publication2012
AuthorsFeng J, Siu VS, Roelke A, Mehta V, Rhieu SY, Palmore TGR, Pacifici D
JournalNano Letters
Volume12
Issue2
Pagination602 - 609
Date Published02/2012
ISSN1530-6992
Keywords; biosensor, focused ion beam (FIB) millin, glucose sensor, nanogrooves, nanoslits, Plasmonic interferometers, surface plasmon polariton (SPP)
Abstract

In this work, we report the design, fabrication, and characterization of novel biochemical sensors consisting of nanoscale grooves and slits milled in a metal film to form two-arm, three-beam, planar plasmonic interferometers. By integrating thousands of plasmonic interferometers per square millimeter with a microfluidic system, we demonstrate a sensor able to detect physiological concentrations of glucose in water over a broad wavelength range (400–800 nm). A wavelength sensitivity between 370 and 630 nm/RIU (RIU, refractive index units), a relative intensity change between 103 and 106 %/RIU, and a resolution of 3 × 10–7 in refractive index change were experimentally measured using typical sensing volumes as low as 20 fL. These results show that multispectral plasmonic interferometry is a promising approach for the development of high-throughput, real-time, and extremely compact biochemical sensors.

URLhttp://pubs.acs.org/doi/full/10.1021/nl203325s
DOI10.1021/nl203325s
Short TitleNano Lett.