The Cancer Biology Program brings together basic and translational investigators with expertise in mechanisms of cancer development, cell signaling, DNA repair, aging, stem cells, genomics, and tumor heterogeneity. Program meetings are held every two weeks throughout the year. Several program members have expertise in toxicology including activity of heavy metals and toxic waste that may impact on cancer rates in Rhode Island. The group is interdisciplinary and includes members from several basic and clinical departments with laboratories at Brown University, Lifespan and their affiliated hospitals.
The goal of program meetings is to bring members together to foster collaborative research in basic and translational cancer biology while taking advantage of advanced technologies and capabilities provided as services through core facilities. Efforts to translate novel concepts are supported by the Translational Research Disease Groups (TRDGs) which are additional cancer disease-based group meetings that occur in parallel to the Cancer Biology Program Meetings. Each of the 11 disease-based TRDGs meets every 2-3 months, with emerging projects being presented at the Cancer Biology Program meetings.
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Robert Sobol, PhD
Professor of Pathology and Laboratory Medicine, Cancer DNA damage and repair, DNA replication, Environmental toxicology, mouse models, NAD (Coenzyme) , PARP
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Anatoly Zhitkovitch, PhD
Professor of Medical Science, DNA repair and cancer, Formaldehyde Genotoxicity, Genotoxicity of Chromium Compounds
Group Members
Elizabeth O Harrington, PhD
Associate Dean for Graduate and Postdoctoral Studies in the Division of Biology and Medicine, Professor of Medicine
Blanche C Ip, PhD
Assistant Professor of Molecular Pharmacology, Physiology and Biotechnology (Research
Shuping Tong, MD, PhD
Associate Professor of Medicine, Division of Gastroenterology Brown University
Laurent Brossay, PhD
Charles A. and Helen B. Stuart Professor of Medical Science, Chair of Molecular Microbiology and Immunology, Professor of Molecular Microbiology and Immunology
Jeffrey A. Bailey, MD, PhD
Associate Professor of Pathology and Laboratory Medicine, Burkitt’s Lymphoma, Computational Biology, Genetics
Paul Bertone, PhD
Core Director (Single Cell Technologies); TRDG Member, Bioinfomatics Single cell profiling
Michelle Dawson, PhD
Quantitative biophysical analysis, Cell-matrix interactions, Tumor heterogeneity
Patrycja Dubielecka-Szczerba, PhD
TRDG Co-Leader (Hematological Malignancies). Core Director (CyTOF); Stem cell biology, Abl kinase, Bone marrow microenvironment.
Nicolas Lux Fawzi, PhD
The structure, dynamics, interactions of large assemblies of intrinsically disordered proteins
Stephen L Helfand, MD
Professor of Biology, Vice Chair of Neurology, Molecular genetics of aging and longevity.
Olin Liang, PhD
Core Director (Lentivirus); Endothelial-tohematopoietic transition, Stem Cell Biology
Attila A Seyhan, PhD
Director of Translational Oncology Operations, Joint Program in Cancer Biology, Brown University and Lifespan Cancer Institute; Core Director of Translational Oncology; Adjunct Associate Professor, Tumor metabolism and RNA processing
Xiaobing Tian, PhD
Core Director (Organic Synthesis); Research Assistant Professor, Integrated stress response, Cell signaling, Myc, Puma, p53
Ashley E. Webb, PhD
Neural stem cell quiescence, aging, cognitive function, learning and memory, age-dependent diseases such as Alzheimer’s disease and vascular dementia
Shengliang Zhang, MD, PhD
Core Director (Drug Discovery); Research Assistant Professor, ROS, ERK2, MDM2, p53
