Misregulated genes may have big autism role

Implicated in rare forms of autism, two genes may have wider role

Matthew Schewede, left, and Eric Morrow learned the value of studying rare forms of autism. Research is done not only for the patients who have rare conditions, but also because doing so can inform research about other forms of autism.

A genetic pathway involving proteins in the endosomes of cells appears to be misregulated in the brains of children with autism, according to a newly published statistical analysis in the journal Molecular Psychiatry. Previously the genes were shown to cause rare forms of the disease but the new study suggests they have a wider role.