Advance in tuberous sclerosis brain science

Brain disrupted

Neurons from the thalamus of control mice with healthy genes glow green (left), while those whose two Tsc1 alleles were deleted during embryonic development show a strong red glow (right), indicating disruption of the mTOR pathway that regulates growth. Credit: Zervas Lab/Brown University

By manipulating the timing of disease-causing mutations in the brains of developing mice, Brown University researchers have found that early genetic deletions in the thalamus may play an important role in course and severity of the developmental disease tuberous sclerosis complex. Findings appear in the journal Neuron.