![](https://www.brown.edu/academics/tsgp/sites/tsgp/files/images/people/Jose%20Mercado-Ortiz_0.jpg)
Fawzi Lab
Biography
I am interested in understanding the mechanisms of interaction and RNA granule association of TDP-43, an intrinsically disordered protein associated with several neurodegenerative diseases including ALS, frontotemporal dementia and Alzheimer’s Disease. More specifically, I use biophysical and biochemical techniques like NMR spectroscopy to study how structure and disease mutations in TDP-43 affect phase separation and aggregation.