The Chellappa lab is dedicated to understanding how metabolism drives complex phenotypes in mammals using stable isotope tracing and metabolomics. We use a combinatorial approach at the interface of genetics, biochemistry, multi-omics, and physiological measurements to understand how metabolism goes haywire across biological scales in aging, obesity, cancer, and neurodegenerative diseases. Our research interests span from identification of biomarkers and therapeutic targets, elucidating disease mechanisms, host-microbiome interactions, to deep diving into the dark matter in human metabolomics.