The Holder Lab is a translational science cancer research lab. We focus on research (basic science and pre-clinical) with a short path to application in the clinic in the form of clinical trials. Thus the three pillars of our research activities are: identify, investigate, and implement. We seek to identify novel targets for cancer therapy, investigate the molecular mechanisms associated with the oncogenicity of the identified targets, and implement clinical trials that interrogate the applicability of those targets for therapeutic use. Historically the Holder lab has been particularly focused on PIM1 kinase as a therapeutic cancer target, and this interest continues.