Research Projects

Sohini Ramachandran head shot
Sohini Ramachandran, PhD

Incorporating Ethnic and Gender Disparities in Genomic Studies of Disease

Dr.Sohini Ramachandran will develop new computational and analytical methodologies to identify risk alleles for leukemia that differ in incidence across ethnic groups and genders, and apply these methods to genome wide association studies. Analyses of X-linked factors offer new insights into human genomic variation.

Alper Uzun, PhD

Computational Genomics of Preeclampsia

In the post genome era, biological research and genomic medicine have been transformed by high-throughput technologies.  New techniques have enabled researchers to investigate biological systems in great detail.  Nonetheless, the extraordinary amount of information in the large number of emerging high-dimension datasets has not been fully exploited.  Increasingly, pathway analysis and other a priori biological knowledge based approaches have improved success in extraction of valuable information from high-throughput experiments and genome-wide association studies.  Preeclampsia is a complex

Shipra Vaishnava, PhD

Spatial and Functional Organization of Intestinal Microbiome

The most prominent diseases of modern times--including inflammatory bowel diseases (IBD) such as Crohn's, ulcerative colitis, and colon cancer as well as metabolic diseases such as diabetes and obesity--are caused as a result of failure to maintain homeostatic interactions with commensal bacteria.  However, at the moment, we do not fully understand the mechanisms that regulate host-microbe interactions.  Moreover, attempts to identifiy common microbiome associated patterns linked with these diseases have either failed or are inconsistent at best.  It is likely that the intestinal flora is s

Nicola Neretti, PhD

A Drug Repositioning Strategy for Healthspan Extension

Aging is the single most important risk factor for a wide range of chronic illnesses, including diabetes, heart disease, cancer and neurodegenerative diseases. Hence, interventions that can slow aging have the potential to prevent or at least retard the onset of these debilitating diseases.  It was recently discovered that senescent cell clearance in mouse aging models improves healthspan and extends lifespan.

Amanda Jamieson, PhD

Tolerance of Viral/Bacterial Co-infections

While infection biology has largely focused on studying the immune response to a single infection, it is becoming increasingly clear that many infections involve more than one pathogen.

Peter Belenky head shot
Peter Belenky,PhD

The Role of Tolerance and Resistance Mechanism in the Response of the Microbiome to Antibiotics

The mismanagement of antibiotic therapy leads to multiple microbiome-related diseases and the spread of antibiotic resistance that compromises our abi