In the post genome era, biological research and genomic medicine have been transformed by high-throughput technologies. New techniques have enabled researchers to investigate biological systems in great detail. Nonetheless, the extraordinary amount of information in the large number of emerging high-dimension datasets has not been fully exploited. Increasingly, pathway analysis and other a priori biological knowledge based approaches have improved success in extraction of valuable information from high-throughput experiments and genome-wide association studies. Preeclampsia is a complex