Brown University’s Institutional Biosafety Committee (IBC) is responsible for regulating the use of biohazardous agents to ensure compliance with appropriate regulations and guidelines and to safeguard the health and safety of Brown University personnel and the community. The Committee serves as the official regulatory body of the faculty and staff in all matters relating to the use of biohazardous agents in basic research. The Committee also serves as the Institutional Biosafety Committee as defined in the National Institutes of Health Guidelines for Research Involving Recombinant DNA Molecules (Federal Register, Wednesday, October, 2011.)
A biohazardous agent is one that is biological in nature, capable of self-replication and has the capacity to produce deleterious effects upon other biological organisms, particularly humans. The IBC, in its scope and function, defines a biohazard as: Biological agents or substances present in or arising from the work environment which present or may present a hazard to the health or well-being of the worker or the community. Biological agents or substances which could be biohazardous include, but are not limited to, infectious or parasitic agents; non-infectious microorganisms such as some fungi; yeasts and algae; plants and plant products, and animals and animal products which cause occupational disease.
Categories of Biohazardous Agents:
A. Any use of agents listed as select agents or biological toxins (42 CFR 73) whether or not pathogenic or exempt from the federal regulations.
B. Any rDNA work including that exempt from NIH guidelines.
C. Transgenic animals that require BSL- 2 housing or BSL-1 housing but have more than 50% of the genome of an exogenous eukaryotic virus from a single family. Or BSL-1 housed rodents in which the transgene is under the control of gammaretroviral long terminal repeat.
D. Human or Non-Human Primate blood, body fluids, tissues and/or cell lines.
E. Infected clinical specimens/ biologically contaminated specimens.
F. Tissues from experimental animals.
G. Any potentially infectious animals or animal tissues.
H. Cultured animal cells and Microbial agents pathogenic to humans, plants and/or animals.
I. Bacterial pathogens e.g.,
Rickettsiae, Chlamidiae. or Bacteria with drug resistant plasmids.
K. Viruses e.g., Oncogenic, Animal/plant, Viral vectors.
L. Fungi and Fungal Pathogens.