Since its inception in 1993, the Brown BTRC has facilitated research into Alzheimer's Disease and other neurodegenerative diseases, stroke, and mental illnesses. The majority of the investigators interested in the Brown BTRC have been affiliated with the memory disorders clinics at the teaching hospitals of the Warren Alpert Medical School at Brown University. Efforts are underway to educate Brown community and the public about the importance of the support for BTRC and brain donation, respectively, to support high quality research of the pathology of Alzheimer’s Disease and other brain disorders.The Brown BTRC draws upon the collective expertise of a variety of investigators engaged in the research of brain diseases. The success of this facility depends on the enthusiastic participation and institutional support of the Brown University affiliated physicians and scientific investigators. Most donations have been obtained from patients diagnosed with Alzheimer’s Disease or other neurodegenerative diseases. Approximately 20% of specimens are from healthy individuals, many of whom had close relatives suffering from Alzheimer’s Disease. An important goal here is to develop a facility that not only receives a variety of cases, but also obtains brains from individuals with no neurological diseases, a vital resource for distinguishing normal from abnormal brain tissue findings.