Date February 1, 2019
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Confronting Opioids

Jody Rich recalls sitting in the Rhode Island Medical Examiner’s office in Providence, a two-foot high stack of folders piled on the table in front of him.

The files contained a large part of the story of the opioid epidemic in Rhode Island: autopsies and toxicology reports, police reports and witness statements, medical records and death scene photographs.

Jody Rich and Brandon Marshall walking across campus
Jody Rich (center), and Brandon Marshall are developing new strategies to reduce opioid overdoses.

“This whole time you’re reading through this folder … you know how it’s going to end: it’s tragic,” said Rich, professor of medicine and epidemiology at Brown. “It’s the death scene photographs—you can’t unsee those. One image was a woman who was pregnant and had a baby shower earlier in the day, and in the photo she is just slumped among all the presents she had just received. It weighs on you, the magnitude of this epidemic and tragedy.”

In the four years before Rhode Island Gov. Gina Raimondo took office in 2015, opioid deaths in the state nearly doubled. One of her first moves in office was to create a task force to confront the opioid epidemic, and she tapped three experts from Brown—Rich; Brandon Marshall, an associate professor of epidemiology at Brown’s School of Public Health; and Traci Green, an adjunct associate professor of emergency medicine and epidemiology—to help lead the way.

Portrait of Traci Green
Traci Green is an associate professor of emergency medicine and epidemiology.

“As expert advisors, we had 90 days to come up with an actionable plan to confront the crisis,” Rich said. “So we scrambled. And Traci, she’s brilliant. She said, ‘We have to find out why people are dying. We have to go to the medical examiner’s office.’”

Green’s instincts were correct, and their hours spent combing through files yielded important answers—prominently, that heroin laced with fentanyl, a highly potent opioid, was often the cause of these overdose deaths. This insight led to action, including a groundbreaking program of addiction treatment for prisoners in the state.

In Rhode Island, overdose deaths increased by nearly 90 percent between 2011 and 2017, with 250 to 300 people dying annually. In 2017, more than 70,000 Americans died from overdoses, according to the Centers for Disease Control and Prevention, and the U.S. Department of Health and Human Services officially declared the opioid crisis a public health emergency.

Reasons For Hope

“Research into opioid use and treatment is an urgent national priority. Against this bleak picture of a national opioid crisis, though, Rhode Island and Brown University have offered reasons for hope,” said Brown University President Christina Paxson, speaking at an October 2018 “Frontlines of the Opioid Crisis: Innovative Science-Based Solutions” event at Brown cosponsored by the American Academy of Arts and Sciences.

“In 2017, opioid-related deaths have dropped … in Rhode Island, the first significant decline in almost a decade. And the state and Brown continues to be widely recognized for generating innovative research and treatment plans that are helping to ease the crisis, and which could provide models for the rest of the country,” Paxson said.

Efforts to combat drug use in the United States have long focused on incarceration and criminal justice deterrents. However, Rich, Green, and Marshall all found through their research that criminal justice efforts are not the most effective ways to deter or rehabilitate people who use drugs. Much of their work offers an alternative focused on expanding treatment and rehabilitation options, and reducing the stigma around opioid addiction.

“Instead of bringing people into the criminal justice system, we need to bring them into treatment,” Rich said. “Individuals don’t die of opioid overdoses because we didn’t have enough arrests, incarceration, or police presence. They die because we have too much of that and not enough treatment.”

Instead of bringing people into the criminal justice system, we need to bring them into treatment.

– Jody Rich, Professor of Medicine and Epidemiology

Rich is the director of the Center for Prisoner Health and Human Rights at the Miriam Hospital in Providence, and he has been treating prison inmates for the past 25 years. In 2018, he was elected to the National Academy of Medicine—regarded as one of the highest honors in the fields of health and medicine—for contributions that include his work on opioids.

His usual routine of biking on Tuesday mornings to the prison where he works has remained unchanged over those years, but in 2016, his research led treatment plans to change dramatically. He and Green helped Jennifer Clark, medical director at the Rhode Island Department of Corrections and a fellow faculty member at Brown’s Warren Alpert Medical School, as Clark launched a new treatment program that is still the only one of its kind in the United States.

It treats inmates, using medication for addiction treatment—drugs like methadone, buprenorphine, and naltrexone—which helps wean them off drugs and reduces risk of overdose upon release. Other programs use one of these drugs, but Rhode Island’s is the only one to offer all three options. In the first year of this program, post-incarceration overdose deaths decreased by 61 percent, contributing to a statewide 12 percent drop in overdose deaths. The team published its findings in a JAMA Psychiatry study in February 2018 that attracted wide attention.

Research by Rich and others has shown that treating people with effective medications—rather than them stopping “cold turkey”—is more successful in fighting opioid addiction. Inmates are at higher risk of overdose when they are released if they don’t receive treatment while imprisoned.

“They may have stopped using because they are incarcerated, but nothing has been done to change the pathways in the brain responsible for addiction,” Rich said.

New Center Of Excellence

Rich is also the principal investigator of the new Center of Biomedical Research Excellence on Opioids and Overdose at Rhode Island Hospital, created in 2018 with an $11.8 million federal grant. Green is codirector of the center, and Marshall is a core director. Their work will focus on understanding more about the causes of opioid addiction, as well as exploring further treatment methods.

Marshall brings another dimension to opioid efforts, focusing on harm reduction strategies because, he said, “Not everyone is ready for treatment. We need to keep people alive long enough to be willing to accept treatment. I see harm reduction programs as working arm in arm with addiction treatment strategies.”

After conducting a study with rapid-acting fentanyl test strips in 2017, he found test strips have the potential to make a big impact. In the year prior to the study, 56 percent of drug deaths in Rhode Island occurred because of fentanyl-laced drugs, primarily heroin. The strips work like an over-the-counter pregnancy test to warn drug users of the presence of fentanyl.

Marshall and his research team provided test strips to drug users and found that they not only used the strips, but often changed their behavior to reduce overdose risk. “The work we’ve done has shown that most people who use illicit drugs or opioids would very much like to avoid fentanyl,” Marshall said.

Marshall’s study, published in the International Journal of Drug Policy in October 2018, showed that fentanyl test strips could help reduce overdoses. He is now expanding the study to a bigger sample size.

He is also using a new $800,000 grant from the Laura and John Arnold Foundation to study the influence of peer recovery support specialists, who have been through their own addiction and recovery, and work at emergency departments throughout Rhode Island with patients who have overdosed.

In addition, Marshall is the scientific director of PreventOverdoseRI.org, the information dashboard and online presence for the state’s drug overdose task force. Using infographics, interactive maps, charts, and videos, the site provides resources for individuals at risk or their friends and family members. Epidemiological data are updated regularly by Marshall and his team of undergraduate and graduate researchers at the Brown School of Public Health.

The facade of the Adult Correctional Institution in Cranston, Rhode Island
Addiction treatment for Rhode Island prison inmates has reduced overdose deaths.

“By understanding where overdoses are occurring and who is most affected, we can develop programs that more effectively respond to the needs of communities across Rhode Island,” Marshall said.

On another front, along with colleagues at Rhode Island Hospital, Boston University, and the University of Rhode Island College of Pharmacy, Green is leading a study to understand how to boost access to naloxone, a medication to counter overdoses, through pharmacies.

CVS Pharmacy, headquartered in Woonsocket, R.I., and several independent pharmacies are collaborators, and have substantially increased their naloxone disbursement as a result of the study.

Green said a separate study is training and equipping Rhode Island pharmacies to provide medication treatment for addiction care.

“In crisis comes opportunity,” said Green. “The pharmacy could be a new partner to provide better, patient-centered care for opioid-use disorder, like we have seen in the prison and jail. We think this could be a game-changer for addiction care.”

Other opioids efforts continue to broaden at Brown. The Association of American Medical Colleges gave the Warren Alpert Medical School a 2018 curricular innovation award for how it advanced the education and training of students, residents, and practicing physicians about opioids.

While overdoses are decreasing in Rhode Island, Rich, Green, and Marshall say there is a long road ahead. Next, they want to share more of their research and data-driven policy advising with other states and address the crisis nationwide. Green said that, because Rhode Island is a small state, the statewide efforts here can be applied at the county level in larger states.

“This is the service part of academic work,” Green said that because Rhode Island is small, statewide efforts can be applied at the county level in larger states., the only constant was that the deaths were going up. But the community came together and we were very strategic and intentional about evidence-based decision making. The data, the deaths, and the patterns showed us a way forward.”