Date December 10, 2024
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What to know about the first overdose prevention center in the U.S., from the researchers studying it

With the first state-sanctioned overdose prevention center about to open in Providence, Rhode Island, Brown University epidemiologist Brandon Marshall explained how researchers will measure its impact.

PROVIDENCE, R.I. [Brown University] — A team of researchers at Brown University has been laying the groundwork for a comprehensive evaluation of the first state-sanctioned overdose prevention center, to be located in Providence, Rhode Island, since 2023.

Overdose prevention centers, or OPCs, are community-based spaces where the primary purpose is to reverse overdoses and save lives. At these facilities, staff are ready to intervene if people overdose while using their own pre-obtained substances. The facilities also connect people with health and social services, including drug treatment, harm reduction, medical care, mental health resources and social support. Project Weber/RENEW, a nonprofit that provides harm reduction and recovery support services to people in Rhode Island, will operate the OPC in Providence.

Two years ago, researchers at the Brown University School of Public Health launched a project funded by the National Institutes of Health to evaluate how the Providence OPC, which will open soon, addresses the overdose crisis and impacts the local community. The team is working closely with researchers from NYU Langone Health who are evaluating two OPCs that opened in New York City, which have support from the city but no state approvals.

“The goal is to identify how OPCs operate in the United States,” said Brandon D.L. Marshall, a professor of epidemiology and director of the People, Place and Health Collective at the School of Public Health, who leads the research team at Brown. “If they are working, what makes them particularly helpful for people? In what ways do they connect people to addiction treatment and care? How can they best be integrated into a community that's been hard hit by the nation’s overdose crisis? Those are some of the things we’d like to tease out.”

As Project Weber/RENEW and a range of partners hosted a Tuesday, Dec. 10, ribbon-cutting at the new center on Willard Avenue in Providence, Marshall shared details about the evaluation.

As the nation’s first state-sanctioned OPC opens, what specifically will the study measure?

Our primary goal is to determine how engaging with an OPC impacts the health and well-being of people who use drugs. We will assess outcomes including changes in overdose risk, uptake of treatment for substance use disorder, and engagement with other health and social services. Second, at the community level, we are examining whether neighborhoods surrounding the OPC experience a greater change in overdose rates, measures of drug-related public disorder, and economic conditions following the opening of the OPC, compared to neighborhoods without such a center. Third, we will delve into the role that the operational context, including neighborhood location, program models and operating procedures, plays in shaping the effectiveness of the OPC using qualitative and ethnographic approaches. Fourth, we plan to estimate the costs and cost savings associated with starting up and operating OPCs.

Why is it so important to conduct this kind of an evaluation? 

There are a lot of misconceptions about what OPCs do and how they impact the neighborhoods in which they’re located. People may worry that these sites could increase crime, public drug use or drug-related litter. In order to assuage these concerns and to determine the effectiveness of these sites, we need to use rigorous scientific methods to evaluate them. Beyond anecdotes and passive observations, peer reviewed data will let us know if these sites are working as intended. Whether one supports or is skeptical of these sites, we can agree that good policymaking requires evidence-based data. This evaluation will provide that. 

What have you learned so far, even before the OPC in Providence has opened?

We obtained some pilot funding to conduct interviews with neighbors, business owners and employees in the immediate vicinity of the OPC. We found that 75% of people we spoke with are supportive of the center being in their neighborhood. Some did express uncertainty about the program, or felt like they wanted to learn more or see more of the data, and there were some others who were neutral or didn’t really care. While these results still need to undergo peer review, they represent among the highest levels of public acceptability for OPCs ever observed in the United States.

We have also conducted some qualitative research, led by Adjunct Assistant Professor of Epidemiology Alexandra Collins and now under peer review, asking people who might use the site about their perceptions, concerns and potential barriers. Most people we talked to were aware of the OPC and see its value, but some did express concerns about, for example, law enforcement surveillance and interactions around the OPC, despite its legalization, that would be a barrier to use. That speaks to the need for the center operator to work in collaboration with the Providence Police Department in supporting this legal facility that's operating under a state law, and in developing protection for people who may use it. 

Beyond anecdotes and passive observations, peer reviewed data will let us know if these sites are working as intended. Whether one supports or is skeptical of these sites, we can agree that good policymaking requires evidence-based data. This evaluation will provide that.

Brandon Marshall Professor of Epidemiology
 
Brandon Marshall

How common are these centers in other nations? Have they been effective in reducing overdoses? 

There are approximately 200 OPCs operating in more than 14 countries around the world. The first opened in Switzerland in the 1980s, so they are not a new intervention globally. Studies consistently show substantial public health benefits: for example, one study from France showed an almost 60% reduction in emergency department visits among people who used an OPC compared to people who use other harm reduction programs. I led a study, published in the Lancet in 2011, that demonstrated a 35% reduction in overdose mortality in the immediate vicinity of an OPC after it opened in Vancouver, Canada. Nonetheless, the United States has an overdose crisis unlike any in the world, so it’s important to study how OPCs might be an effective component of a broader continuum of care for people who use drugs in this country.

What are these centers like to visit?

Some are standalone fixed-site facilities, with a reception area, booths for supervised consumption, and other areas where staff help connect clients to resources, treatment and health care. There are also mobile OPCs operating in some countries, which might look like converted RVs or blood donation vans. Regardless of the layout, at all OPCs you’ll find staff who offer services and provide support in a safe, non-judgmental, non-stigmatizing manner. That’s the most critical piece: OPCs are spaces to build connections and trusting relationships to connect people with services and care.

What’s unique about the OPC in Rhode Island?

The OPC in Providence will be the first state-sanctioned facility in the US, which means it operates legally under state law and will be regulated by the state health department. Moreover, in most cities around the world, OPCs are located where there's a lot of overdose activity. The Providence OPC is located in what I would describe as a health care or hospital district; it’s right beside our state’s largest tertiary care center, Rhode Island Hospital, and near other primary care facilities, as well as a new addiction treatment center that opened at Brown University Health. 

We’re very interested in studying the potential value of having the OPC so close to those health care facilities. Previous research has shown that after experiencing an overdose, a lot of people get discharged from the ER with very little resources or support. So my hope is that this center could be a place where people who get discharged could go immediately for some of that additional peer support. We also want to study the extent to which people who use the OPC could be referred to the hospital for more advanced care if they have skin and soft tissue infections, for example.

In what ways will you measure the center’s effectiveness?

One of the key things we want to look at is understanding the pathways through which people move through various systems of care that might start as a result of interacting with the OPC. This is a population which is not typically accessing especially primary care, might have experienced a lot of barriers to accessing addiction treatment, or who struggles with finding housing. We want to learn the extent to which the OPC can help support entry into those systems. 

We're going to do that with a cohort study of 500 people here in Providence and 500 people in New York City. We're collecting a lot of information from participants directly, and then with their consent we’re linking that data to administrative data that the state or city holds on addiction treatment initiation, housing and other services. We're particularly interested, for example, in studying whether using the OPCs increases initiation of evidence-based medications for opioid use disorder like buprenorphine and methadone. I'm excited about being able to study that in a more rigorous way than in other countries, in large part because of the outstanding collaborations we have with our state agency partners.

What are some ways you will measure the impact on the community?

Research assistants have been going out at different times during the day, including weekends and evenings, and are assigned to selected city blocks around the OPC as well as in a different neighborhood. We're doing this for both three months before and after the center opens to observe any changes in neighborhood conditions — changes in discarded syringes, public drug use and police activity, for example. Our team’s research assistants are recording these data in real-time on mobile phones as they're doing these assessments. The second part of that research is using state administrative data to look at broader and longer-team spatial impacts of the OPC on this neighborhood. We'll be requesting data from the health department, for example, on EMS runs for suspected overdoses to look to see if the spatial patterns of EMS runs are changing as a result of the OPC opening.

What else does the study cover, and when do you expect to release findings?

We have a health economics team who will be doing what are called micro-costing methods to understand the cost of both opening and sustaining an OPC, and then we'll look at some of the cost savings as a result of using the OPC. These are the first sanctioned sites nationally, so we only have cost-effectiveness data from other countries, where the health care systems are very different. Some savings we hypothesize might come from use of OPC services include reduced emergency room visits for overdose, or low-threshold health care services provided at the OPC — these are very expensive conditions to treat in an emergency room. 

We want to get this information out as soon as possible, because we know people are curious. As we finish our analyses, we will submit them for publication in peer-reviewed scientific journals. The plan is to be publishing and producing results throughout the course of the study and disseminating our work to policymakers and other stakeholders, as well as the general public over the next three years.