Date July 23, 2026
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Irish Folds: Studying snake vertebrae to decode the mysteries of animal evolution

The rising Brown University senior and biology concentrator is conducting hands-on research with snake specimens at natural history museums and in the lab at Brown to better understand biological diversity.

PROVIDENCE, R.I. [Brown University] — From California to Connecticut, Brown University student Irish Folds has been checking out preserved snake specimens from natural history museums this summer, similar to checking out books from the library, she said.

Natural history museums are treasure troves of biological data that offer researchers access to specimens that have been preserved for years or even centuries, according to Folds. Through her research, she is examining the variation in snake vertebrae among different groups of snakes, which reveals details about evolution and movement.

“Snakes have vastly different numbers of bones, yet they all slither,” Folds said. “So how does the different number of bones contribute to how snakes move? I’m seeing if I can quantify how that variation has evolved or re-evolved and changed throughout populations.”

As a summer research fellow in Brown’s Department of Ecology, Evolution and Organismal Biology, the rising Brown University senior developed her summer research project with guidance from Jessica Tingle, an assistant professor of ecology, evolution and organismal biology whose research focuses on how snakes manage to move in a wide variety of ways through vastly different habitats.

While snakes are infamous in stories going back to biblical times, there’s a surprising dearth of scientific knowledge about these reptiles. Studying snake biomechanics can advance understanding of how snakes as well as humans move, Tingle said, especially when it comes to employing muscles that span multiple joints.

Counting snake scales to unlock evolutionary mysteries

By studying snake vertebrae, Folds is researching how snake species have changed over time and in response to various conditions or events.

While mammals generally have 30 to 50 vertebrae divided into distinct regions, snakes can have between 100 and more than 400 body vertebrae, and between five and more than 200 tail vertebrae. Her goal is to understand biological diversity in the context of evolutionary history. 

“Since this variation of vertebral count is such a cool thing that we don’t understand, I hope to quantify it and to see how this trait functions evolutionarily,” said Folds, who is concentrating in biology and astronomy at Brown. “One of the questions our lab is asking is, ‘How does this variation in vertebrae count affect how snakes’ bodies work?’ My project will help create a foundation of data to help provide answers.”

To research the specimens — which are usually stored in glass jars filled with a liquid preservative that sustains the specimens’ lifelike appearance — Folds counts special scales on a snake’s belly that directly correlate to its number of vertebrae.

As she carefully counts the scales, she marks every group of 10 with a metal pin. Because the specimens are wet, she uses a pen and paper to document her observations and later adds the data into the computer back in the laboratory at Brown.

“It's great to have this incredible way to preserve data that we couldn't otherwise get,” Folds said. “Because of these carefully preserved specimens, I can look back and see what a snake looked like in, say 1930s Wyoming — that information is no longer lost to history.”

Hands-on summer research, from California to Connecticut

Folds is engaging in her summer research project with the support of Brown University’s Maria L. Caleel Fellowship for seniors and rising seniors in Brown’s undergraduate biology program conducting summer research as the foundation for their honors thesis.

Snake studies

 

Rising senior Irish Folds is analyzing snake vertebrae to decode the mysteries of animal evolution. Video by Anthony Saccoccia.

As a Caleel fellow, Folds received a competitive stipend, additional funding for research expenses and professional development opportunities, which has supported her hands-on research in different U.S. locations, including the California Academy of Sciences in San Francisco, where she studied snakes that were more than 100 years old.

A native Californian, Folds is particularly drawn to rattlesnakes, which are iconic in her home state. While also native to the Northeast, rattlesnakes are now scarce in the wild — but are still in plentiful supply in museum collections.

During summer research trips to the Yale Peabody Museum in New Haven, Connecticut, with her Brown University labmates, Folds has been examining timber rattlesnakes, her study specimen of choice.

Since childhood, Folds has been passionate about studying animals and their distinctive characteristics, “from the uncountable specialties fine-tuned to each niche, to the seemingly incongruent features, to the layered meshes of ecological interactions, to the intricacies of every individual motion,” she wrote in her application for the Caleel fellowship. With this project, she’s able to quantify some of those “uncountable specialties.”

Folds hopes to return to museums after summer ends, including the American Museum of Natural History in New York where she would like to collect data from additional specimens. After graduation, she intends to pursue an advanced degree in evolutionary biology and conduct research in a museum setting.

“This is a pretty cool gateway to that goal,” she said.

Folds will present her findings at the University’s Summer Research Symposium in early August and plans to turn her project into an honors thesis.