Brown researchers focus on expanding access to pediatric OCD treatment they helped pioneer

Psychiatry scholars who helped create the gold-standard treatment for pediatric OCD are developing more innovative and accessible delivery methods.

PROVIDENCE, R.I. [Brown University] — One of the most common mental health conditions among American children is obsessive compulsive disorder (OCD) — a reliance on ritual behaviors to counteract persistent distressing thoughts.

The gold-standard treatment for OCD is exposure therapy, which is the process of gradually and thoughtfully exposing someone to the object of their distress, with support. This active, collaborative and creative form of behavioral intervention requires trained practitioners to conduct multiple sessions with young patients and their families. Given a shortage of mental health professionals and rising rates of youth anxiety and depression, this means that the best therapy isn’t always available to the people who need it.

A team of researchers affiliated with the Pediatric Anxiety Research Center at Bradley Hospital and Brown University’s Warren Alpert Medical School is working to change that. They are focused on expanding access to evidence-based exposure therapy and developing new treatment and training methods with technologies including artificial intelligence, virtual reality and magnetic brain stimulation.

The center is distinguished by its iterative approach, said Jennifer Freeman, a professor of psychiatry and human behavior (research) at the Warren Alpert Medical School and director of Brown University Health’s Pediatric Anxiety Research Center

“Our science drives our clinical work, and vice versa,” Freeman said. “The feedback we’ve received from patients and their families has inspired the launch of new research projects. Then that research spawns innovative clinical approaches that are integrated into the care we provide. It’s an iterative and mission-driven system.”

As a postdoctoral researcher at Brown in the early 2000s, Freeman was part of an effort involving researchers from Duke University Medical Center and the University of Pennsylvania that conducted the first large-scale randomized controlled trial for treatment of pediatric OCD. This trial ultimately established the effectiveness of exposure-based cognitive behavioral therapy. 

In follow-up studies, the researchers learned that children with severe OCD need even more intensive exposure therapy, and that family reinforcement is critical. In 2013, Freeman’s team launched a program to put those findings into practice. 

Our science drives our clinical work, and vice versa. It’s an iterative and mission-driven system.

Jennifer Freeman Professor of Psychiatry and Human Behavior (Research), Director of the Pediatric Anxiety Research Center
 
Jennifer Freeman

“Exposure therapy is such a hopeful treatment,” said Dr. Elizabeth Brannan, an associate professor of psychiatry and human behavior and clinician educator at Brown, and the intensive services lead at the Pediatric Anxiety Research Center. “We have kids coming to us whose entire lives are consumed by anxiety or OCD, and two to three months later, they’re going to school and living their lives again. The difference can be shocking.”

Facing fears where they live, with support

Exposure therapy draws on the body’s natural capacity for habituation. Facing a fear is like jumping into cold water, Brannan said: uncomfortable at first, but tolerable with time. The trick is to find creative ways to help a child confront and stay in the feeling of anxiety until it abates. For someone with a phobia of vomiting, for example, an exposure could range from spelling the word “vomit” to watching a video of the act to facing a specific trigger.

Exposures in the center’s intensive program are custom-designed and delivered by a team of psychiatrists, psychologists and trained coaches, for five days a week over two to three months. In addition to regular individual therapy and group sessions, exposure coaches visit the patient at home. The coaches eventually teach families how to lead exposures themselves. 

More than three-quarters of the severely sick kids in the center’s intensive program respond to exposure-based treatment, according to Brannan.

The researchers are testing virtual reality as a training tool to simulate exposure sessions for therapists, and studying transcranial magnetic stimulation — a non-invasive way to activate parts of the brain with magnets — as a way to help the hardest-to-treat patients benefit from exposure therapy.

Freeman calls the team-based model — of doctoral-level clinicians (such as a psychologist with a Ph.D. or a psychiatrist with an M.D.) supervising exposure practitioners who can go virtually anywhere — the center’s most important innovation since its earliest trials. That’s because the approach treats anxiety where it lives: in schools, churches, stores, beaches and more. The Brown researchers recently concluded a five-year study of the effectiveness of this type of program.

In late 2024, researchers at the center were awarded an $11 million federal grant to test the model in community-based health care settings across Rhode Island, which serve more socioeconomically diverse populations. The findings, the researchers hope, will justify insurance coverage for home visits.

While the treatment is accessible to children living in Rhode Island, families from all over the country come to the center, often after a wait, given the demand. Brown faculty continue to pilot and study solutions to the shortage of trained mental health professionals, including a remote training program for individual therapists as well as clinical staff at community centers, schools and psychiatric hospitals. 

“We need to be going outside the safety of our academic medical setting and doing everything we can to treat everybody,” Freeman said.

This story was adapted from a Medicine@Brown feature about the Pediatric Research Anxiety Center.