Date November 26, 2024
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Dominique Pablito: Advancing science while inspiring fellow Indigenous students in STEM

As she investigates cancer treatments and pursues her own path toward becoming a physician-scientist, the Brown University doctoral student is supporting fellow Indigenous students interested in science and medicine.

PROVIDENCE, R.I. [Brown University] — Brown University Ph.D. student Dominique Pablito wears her Indigenous identity proudly.

An aspiring physician-scientist pursuing research in molecular biology, cell biology and biochemistry at Brown, Pablito is simultaneously strengthening support for fellow Indigenous students through mentorship and engagement across campus, including the launch of a new American Indian Science and Engineering Society chapter.

As a fifth-year doctoral student researching treatments for glioblastoma, an aggressive form of cancer, and a member of the Navajo, Zuni and Comanche tribes, she aims to pursue a career in medicine and provide trusted care to tribal communities on reservations.

Dominique Pablito poster session
Pablito wore colorful tribal regalia during a research symposium. Photo by Henry Natonabah III.

“I want to be very truthful about where I come from,” Pablito told her audience during a recent presentation at Brown in which she spoke about her experiences as an Indigenous student and researcher. She projected photos from the science laboratories in which she worked along with photos of the home in which she lived with a dozen family members on the Zuni Indian Reservation in New Mexico. “My ancestors survived America’s attempt on cultural genocide, but the generational trauma remains. I say this because it is truly monumental to be standing before you giving you this presentation.”

With every academic and professional accomplishment she celebrates, Pablito said she feels a responsibility to members of her community who preceded her and those who will follow. She wears beaded jewelry and Indigenous clothing as business attire regularly, and dressed in full tribal regalia to present her findings about glioblastoma at a poster session in October. 

“I’m a mentor for the next generation of Indigenous students, and I’m paving a path for them,” she said.

Embraced at Brown, broadening support to others

Pablito’s doctoral research is focused on identifying new target genes to develop therapeutics to treat glioblastoma, an aggressive malignant tumor that affects the brain.

Her foray into neuroscience was prompted by the experience of her uncle, who had severe epilepsy when Pablito was a child. When his doctors recommended a hemispherectomy — a rare surgery in which half of the brain is removed or severed from the other half — Pablito, who excelled in science at school, pored through medical research to help her family understand what was going on. The more she learned about brain science, the more she wanted to become a neurosurgeon. 

Growing up in the Navajo Nation in Utah and the Zuni Indian Reservation in New Mexico, Pablito also witnessed how distrust of the U.S. government often prevented community members from seeking medical care. She watched family members succumb to ailments that could have been intercepted if they’d had a provider they trusted. So she set a goal of becoming just that kind of doctor.

While studying chemistry in the pre-medicine track at the University of Utah, Pablito participated in a pathways program with the National Cancer Institute and discovered the world of research.

“When I was young, I used to say I wanted a job where I’d never have to stop learning,” Pablito said. “And there is so much to learn about glioblastoma. There are so many problems to solve, such as how to not only develop effective medication, but to find a way to get the right drugs across the blood-brain barrier; how to access tumors deep within the complex structure of the brain; and how to target the malignancy without affecting other functioning areas.”

When she came to Brown in 2019 to explore biomedical science programs during Doctoral Preview Day, Pablito felt particularly welcomed by Alison DeLong, an associate professor in the Department of Molecular Biology, Cell Biology and Biochemistry.

“I was pretty shy, but Alison kept following up,” Pablito said. “This made me feel like she genuinely cared about me, which is a rare feeling among reservation kids pursuing higher education.”

In Providence, Pablito connected with Erica Larschan, joining the associate professor of molecular biology, cell biology and biochemistry’s lab to conduct genetic research on fruit flies. 

Through her study, Pablito has come to appreciate the potential of scientific research to cure ailments on a population-wide scale, she said. She is continuing the cancer research she started during college, collaborating with Dr. Nikos Tapinos, an associate professor and neuroscientist at Brown who focuses on oncology. They’re looking for glioblastoma genes that, when knocked down, induce genomic instability to the point where the glioblastoma cells are no longer able to replicate or proliferate. In Larschan’s lab, Pablito and colleagues created a model with fruit flies that Tapinos’ team can replicate in mice. The goal is that the work will ultimately inform treatments for glioblastoma in humans. 

Pablito said that Larschan has also played a “monumental role” not just as an academic adviser, but in helping her adjust to the culture shock of moving to the East Coast, setting up regular discussions to talk not just about research but how to balance work with a fulfilling and busy life outside of the lab.

During her time at Brown, Pablito has found ways to connect with her Indigenous culture while living more than 2,000 miles away from her own community. She’s attended powwows at Brown and Harvard, and she’s working on sewing beads on her moccasins so she can dance at Brown’s gathering next spring.

Pablito regularly engages with Brown’s Native American and Indigenous Studies Initiative, where she connected with other Native American students and met with elders from local tribal communities. She helped bridge a connection between the initiative and the Society for Advancement of Chicanos/Hispanics and Native Americans in Science, known as SACNAS. She has mentored students as a counselor for SACNAS@Brown, helped host the 2022 New England Regional SACNAS Meeting and served on the executive board for Graduate Students of Color in STEM at Brown. 

While following her own path to becoming a physician-scientist, Pablito is committed to inspiring other Native American students to pursue STEM careers, including through the establishment of the American Indian Science and Engineering Society chapter on Brown’s campus, which began meeting this fall. 

“My goal for starting a chapter at Brown was to establish a working group of Indigenous students who are all interested in science, because just having that community can be extremely beneficial,” Pablito said. “It can help Indigenous students feel more at home and help us perform at our best academically.”

Juggling research, mentorship and preparations for medical school while managing the visible and often-invisible work of serving as a mentor feels at times overwhelming, but it is crucial, Pablito said.

“I think about myself as a child on the reservation, where few students go on to college, and we kind of felt like a lost cause to other people,” she said. “I was deeply touched by those people who did make an effort to reach out to us, and to really see us. The way that I see it, if my work touches the life of even just one young student like me, then it will all be worth it.”