Description

The Department of Molecular Biology, Cell Biology & Biochemistry at Brown University is seeking a Postdoctoral Associate to join the laboratory of Dr. Hongwei Yao, Associate Professor (Research).  Dr. Yao’s laboratory focuses on metabolic reprogramming and senescence during normal lung development, the development of bronchopulmonary dysplasia and associated pulmonary hypertension using human peripheral tissues, small and larger animal models, and cell culture. The laboratory pursues multidisciplinary approaches, including metabolomics, metabolic flux assay, single cell RNA sequencing, genetic lineage tracing, as well as traditional molecular and physiopathological methods. 

The duty of the postdoctoral associate is to study metabolic mechanisms in the pathogenesis of bronchopulmonary dysplasia and associated pulmonary hypertension, as well as to identify therapeutic targets for these diseases using in vitro cell culture, animal models and human peripheral tissues. The postdoctoral associate will perform hyperoxic exposure, drug administration, and nanoparticle-mediated gene delivery. In addition, the candidate is experienced in Western blot, immunoprecipitation, qRT-PCR, immunohistochemistry, immunofluorescence, and biochemical analysis. She or he is willing to learn new techniques, including lineage tracing experiments, single cell RNA sequencing and spatial transcriptomics.  The postdoctoral associate will also assist in the technical training and supervision of technicians and students. The postdoctoral associate will participate actively in relevant seminars, journal clubs and conferences. The applicant will be responsible for generating and preparing the data that will go in reports and presentations as well as for manuscript publications. Finally, the postdoctoral associate will also assist in planning/drafting relevant portions of extramural grants to continue support of the project.

Salary is commensurate with experience, per Brown's postdoctoral salary scale (which matches the NIH Postdoctoral Stipend scale).

Qualifications

Applicants must have completed all requirements for a doctoral degree before start of the position or have completed no more than one prior postdoctoral fellowship. Candidates are expected to have intensive experiences in small animal procedures, cell culture, and/or molecular biology. Candidates with solid background in metabolism, aging/senescence, and/or lung biology are particularly encouraged to apply. Strong time management, communication and writing skills, and the ability to work both independently and as a part of a team are required.

Application Instructions

Applicants should submit a CV, statements of teaching philosophy and research interests, up to three representative publications, and names of three references via Interfolio.

Application review will begin August 15, 2023.

The MCB Department at Brown is committed to centering efforts to diversity, equity and inclusion in all our activities, and to constituting a community that welcomes members regardless of identity. The statement of MCB department Diversity & Inclusion Action Plan includes the commitment to diversity and inclusion on topics of People, Academic Excellence, Curriculum, Community, Knowledge, and Accountability.

The Department of Molecular Biology, Cell Biology, and Biochemistry (MCB) at Brown University is seeking a Postdoctoral Associate to lead one or some of the projects in our research group in the lab of Mamiko Yajima. We are the sea urchin embryology lab and study embryonic development with a focus on 1) asymmetric cell division, 2) metabolic regulation, 3) localized mRNA translation, and network-level analyses.

The position is intended for wet lab work, yet many of the projects integrate large dataset analysis, which will be supported by our computational biologists in the group. This position will be ideal for those who are interested in integrating both experimental and computational biology into one’s research.

Project description:

1)  Molecular evolution of polarity factors and asymmetric cell division: Discovering how molecular evolution of AGS, a polarity factor, alters the asymmetric cell division and developmental program during the course of echinoderm evolution (Reference article)

2)  Metabolic regulation during embryonic development: Identifying how metabolic regulation contributes to specific cellular signaling and gene regulations during asymmetric cell division of the sea urchin embryo

3)  Localized mRNA translation on the spindle: Identifying how Vasa, an RNA helicase, regulates translation with spatiotemporal precision during asymmetric cell division of the sea urchin embryo (Reference article)

Qualifications

Requirement: General knowledge and skills in cell and developmental biology.

Preferred skills: Experience in embryology and live imaging such as microinjection, optogenetic manipulations of a protein, and 4D-confocal imaging is preferred. Experience or knowledge in systems biology and/or multi-omics analyses is also welcomed.

Applicants must have completed all requirements for a doctoral degree before start of the position. Salary will be based on the NIH Postdoc scale that Brown follows and is commensurate with experience. 

Application Instructions

Applicants should submit a CV, cover letter, up to three representative publications, and names & contact of three references via Interfolio: https://apply.interfolio.com/126955.  Application review will begin immediately. 

The MCB Department at Brown is committed to centering efforts towards diversity, equity and inclusion in all our activities, and to constituting a community that welcomes members regardless of race, ethnicity, nationality, gender, sexual orientation, religion, age, and ability. These goals are grounded in our awareness of biases and barriers in STEM and in academia that weaken community and impede scientific progress and innovation.

Thus, we strive to be a community in which a diverse set of thoughts, perspectives and experiences are valued. We believe that everyone here should have a seat at the table and be given the opportunity to bring out their best in an environment where an individual’s strengths and specific challenges are recognized, and where as a community we work towards elevating every individual while collectively lowering barriers that impede them. We are a community committed to educating ourselves, to learning about and from each other, and to openly discussing biases, barriers and inequities that some of us may face, while committing ourselves to recognizing and eliminating them. We are committed to bringing this effort of equity-mindedness to our research laboratories, our classrooms, our meetings and our social events. In instances where we fail to do so, we commit to accepting feedback, learning from our mistakes and working to improve. We are also committed to actively combating racism and racist practices, advocating for and bringing about institutional change, and serving as a role model for the rest of the university.

Description

The Postdoctoral Associate will design and perform experiments centered on the neural mechanisms of sequential control using nonhuman primate (NHP) behavior, functional magnetic resonance imaging (fMRI), electrophysiological recordings, and/or computational methods. The Postdoctoral Associate will also be responsible for performing data analyses and drafting manuscripts of findings. The Postdoctoral Associate will be involved in the mentorship of more junior lab members and strongly encouraged to present scientific research at applicable conferences and apply for relevant funding. All lab activities will be developed with and overseen by Dr. Desrochers.

Qualifications

Applicants should have a strong background in systems neuroscience, behavioral training, electrophysiology, or fMRI. Strong quantitative skills and previous experience with animals and/or NHPs is preferred. Applicants must hold a Ph.D. in Neuroscience, Psychology, or a related discipline or must show evidence that the Ph.D. will be completed before the start of the position. This funded position is initially for 12 months with the possibility of renewal. Compensation will be commensurate with relevant experience according to the NIH scale.  

The Neuroscience department at Brown is committed to centering efforts towards diversity, equity and inclusion in all our teaching, mentoring and research. This is grounded in our knowledge that the best science requires an inclusive environment, and that long-standing biases exist in STEM that negatively impact members of our community and science as a whole. Thus, we strive to be a community in which a diverse set of thoughts, perspectives and experiences are valued. One where anybody, regardless of race, ethnicity, nationality, gender, , sexual orientation, religion, age, and ability feels that they are welcome here and belong here. We believe that everyone here should have a seat at the table and be given the opportunity to bring out their best in an environment where an individual’s strengths and specific challenges are recognized, and where as a community we work towards elevating every individual while collectively lowering barriers that impede them. We are a community committed to educating ourselves, to learning about and from each other, and to openly discussing biases, barriers and inequities that some of us may face, while committing ourselves to recognizing and eliminating them. We are committed to bringing this effort of equity-mindedness to our research laboratories, our classrooms, our meetings and our social events. In instances where we fail to do so, we commit to accepting feedback, learning from our mistakes and working to improve. We are also committed to actively combating racism and racist practices, advocating for and bringing about institutional change, and serving as a role model for the rest of the university.  https://www.brown.edu/academics/neuroscience/home

Application Instructions

Review of applications will begin immediately and will continue until the position is filled or the search is closed. Please apply via Interfolio. 

For more information, please contact [email protected]. 

Equal Employment Opportunity Statement

Brown University is committed to fostering a diverse and inclusive academic global community; as an EEO/AA employer, Brown considers applicants for employment without regard to, and does not discriminate on the basis of, gender, sex, sexual orientation, gender identity, national origin, age, race, protected veteran status, disability, or any other legally protected status.

Description

Applications for Postdoctoral Research Associate are being sought for a unique opportunity to study sequential control in the laboratory of Dr. Theresa Desrochers in the Department of Neuroscience at Brown University. Successful candidates will have interest in human behavior, fMRI, TMS, computational psychiatry, and OCD. The Desrochers Lab provides a unique cross-level and cross-species training environment situated within a highly collaborative research environment fostered by Brown University and the Carney Institute for Brain Science.

Qualifications

Prior experience in human neuroimaging and strong quantitative skills are preferred. All interested candidates regardless of level of experience with these methods are encouraged to apply. Applicants must hold a Ph.D. in Neuroscience, Cognitive Science, Psychology, or a related discipline or must show evidence that the Ph.D. will be completed before the start of the position.

Application Instructions

Brown University is an EEO/AA employer and encourages applications from minorities and women. Review of applications will begin immediately and will continue until the position is filled or the search is closed. For more information, please contact [email protected]. Please apply in Interfolio:  https://apply.interfolio.com/87606

Brown University is committed to fostering a diverse and inclusive academic global community; as an EEO/AA employer, Brown considers applicants for employment without regard to, and does not discriminate on the basis of, gender, sex, sexual orientation, gender identity, national origin, age, race, protected veteran status, disability, or any other legally protected status.