Feb254:00am170 Hope Street
Monday, February 25, 2019
Room 108, 170 Hope Street
Thomas Michael, Harvard
Title: Bridging time and length scales in filamentous protein self-assembly
Abstract: Filamentous protein self-assembly is a process in which dispersed proteins assemble spontaneously to form ordered elongated structures. This phenomenon is an essential characteristic of life, finds widespread use in numerous nanotechnological applications, but is also at the heart of pathologies of many types, including Parkinson’s and Alzheimer’s diseases. To exploit protein self-assembly for nanotechnology or curtail it for medical purposes it is necessary to quantify the fundamental principles that control the way dispersed molecules assemble into these ordered structures. The fundamental challenge in establishing such an understanding in a rigorous manner is the disparate nature of the spatial and temporal scales involved. In this talk, I demonstrate how we can address this challenge by bringing the power of physical methods to protein self-assembly to connect microscopic mechanisms with macroscopic observations of such phenomena. In a first part of the talk, I discuss a unified theory of the kinetics of filamentous protein assembly and show how these results reveal simple rate laws that provide the basis for interpreting experimental data in terms of specific mechanisms controlling the proliferation of fibrils. I will then discuss how the resulting methods can guide us in the development of rational strategies for controlling aberrant protein aggregation in time and space. I will bring together protein aggregation kinetics with optimal control theory to determine explicit optimal administration protocols of drugs that inhibit specific molecular events during the aggregation process. I will also introduce ideas from liquid-liquid phase separation to investigate how liquid cellular compartments could be implicated in spatially regulating protein aggregation.
Feb255:30pm - 7:00pmSmith-Buonanno Hall
Please join the Brown Contemplative Studies Initiative for a lecture by Reverend Takafumi Kawakami entitled, “Self-Cultivation and the Difference between Reality and Actuality,” on Monday, February 25th, from 5:30 pm - 7 pm at Smith-Buonanno, Rm. 106. This event is free and open to the public.
Reverend Takafumi Kawakami is the Vice Abbot and International Affairs Coordinator of Shunkoin Temple in Kyoto, which is the headquarters of the largest Rinzai Zen Buddhist school in Japan. He annually teaches Zen Buddhist classes in English to 5,000 – 5,500 visitors to the temple and he delivered the popular TEDxKyoto talk on “How Mindfulness Can Help You Live in the Present.” In
addition, he is an LGBTQ rights supporter, and Shunkoin is the first Buddhist temple in Japan that publicly offers same-sex wedding ceremonies. He is also a Fellow of the U.S.-Japan Leadership Program for the U.S.-Japan Foundation and a Researcher at the Keio Media Design in Keio University.
Feb257:00pm - 8:30pmSalomon Center for Teaching
In our ongoing effort to raise awareness and erase the stigma associated with the opioid epidemic, ABC6 is teaming up with the Brown University School of Public Health, the RI Department of Health, the RI Quality Institute, and the City of Providence Healthy Communities Office to produce a televised panel discussion, “The Opioid Crisis: Where We Stand Now”.
This discussion is a continuation of ABC6’s “Addiction Hitting Home” program initiative, striving to connect Southern New Englanders with the latest information on the opioid epidemic in our communities. This month, ABC6 is airing a series of special reports examining the severity of the crisis and where we have come since our Town Hall Special one year ago. The series will culminate with our televised event, which will be held at Brown University’s Salomon Center for Teaching on February 25th at 7PM. It will bring together mental health and addiction experts, first responders, and Southern New Englanders directly impacted by the epidemic. The program will air on ABC6 on February 27th from 7 to 8PM.
Hosted by ABC6 Anchors John DeLuca and Christina Myers.
Included Panelists: Brandon D.L. Marshall, PhD., Brown University School of Public Health; James McDonald, MD, MPH, RI Board of Medical Licensure and Discipline; Capt. Zachariah Kenyon, Providence Fire Department, Providence Safe Stations; Linda Hurley, President/CEO of CODAC Behavioral Healthcare; Southern New Englanders directly impacted by addiction.
Feb2612:00pm - 6:00pmFaculty Club
The Office of the Vice President for Research is conducting this training workshop designed to assist in effectively disseminating scientific knowledge to a broad audience. Developed specifically for Brown faculty in the life and physical sciences, the workshop will feature media training and panel discussions by professionals at and beyond Brown with expertise in communicating with the general public and government officials.
Overview and Media Training
- 12:00 to 12:45 Lunch and Remarks from Jill Pipher: Why this, Why now?
- 12:45 to 2:15 Media Training 201: Effectively Amplifying Your Research
- 2:30 to 3:30 Communications: Translating Science for a General Audience
- 3:30 to 4:30 Government Relations: Making the Case for Science to Government Officials
- 4:30 to 6:00 Informal discussion and Reception
Space is limited! Remember, please RSVP to secure your seat.
Participants may register for part of the day or the full conference.
Feb278:00am - 9:30am
Department of Neurology Grand Rounds- “Strange spikes and peculiar synapses: Things textbooks don’t say about how the brain works”Rhode Island Hospital
“Strange spikes and peculiar synapses: Things textbooks don’t say
about how the brain works”
8:00-9:00 a.m. Barry W. Connors, PhD, Professor of Medical Science, L. Herbert Ballou University; Professor of Neuroscience, Department of Neuroscience, Brown University
Objectives: At the conclusion of this session, participants should be able
9:00-9:30 a.m. Case Presentation:
Andrew Blum, MD
Rhode Island Hospital is accredited by the Rhode Island Medical Society to provide continuing medical education for physicians.
Rhode Island Hospital designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
To request reasonable accommodation for a disability, please contact The Rhode Island Hospital CME office at (401) 444-4260.
Feb271:00pmRhode Island Hospital- Ambulatory Patient Center
Title: “Delirium and Dementia
Speaker: Michael Reznik, MD, Assistant Professor The Warren Alpert Medical School, Department of Neurology, Rhode Island Hospital
Time: 1:00PM - 2:00PM
Location: Ambulatory Patient Center (APC Building), Leone Conference Room 133,
Rhode Island Hospital
Feb2812:00pm - 1:30pmSharpe Refectory
Carney Innovations Awards
Robert J. & Nancy D. Carney Institute for Brain Science Lunch Talk
Thursday, February 28
12 - 1:30 p.m.
Sharpe Refectory, Chancellor’s Dining Room
Learn more about the Innovation Awards program and hear from some recipients of prior awards.
Feb284:00pmSidney E. Frank Hall for Life SciencesMechanisms of curiosity and information samplingin humans and animals
Mar112:00pm - 1:00pm121 South Main Street
Please join the Department of Behavioral & Social Sciences for our i-BSHS Lecture Series with Dr. Jaime Booth. She will be giving her lecture titled, “Understanding youths’ exposure to neighborhood stressors in real time: A youth engaged pilot test of EMA methods and measures” on March 1st at 12pm at 121 South Main St, Room 245.
We look forward to seeing you there!
Mar45:00pm - 6:30pmWomen & Infants Hospital
Register now for, “Better Together: Putting Team Science Theory into Practice to Enhance Your Research,” a workshop presented by Debbie Cornman, PhD, and Katie Sharkey, MD, PhD.
Medical research continues to move away from the traditional “independent investigator” model, and toward collaborative approaches that integrate diverse disciplines with traditional biomedical sciences.
The National Institutes of Health established team science approaches as a major goal in its 2003 Roadmap . Yet, despite educational efforts and funding incentives, barriers toward achieving this goal remain. Many investigators are not aware of how to implement team science approaches into their research, or utilize available support.
In this workshop, Debbie Cornman, PhD and Katie Sharkey, MD, PhD will discuss the latest findings in the “science of team science,” and teach investigators how to implement strategies and techniques for successful team science approaches into their own research.
By the conclusion of the workshop, attendees will:
- Discuss the theories behind a team science approach
- Appraise their own readiness for engaging in team science
- Apply the team science approach to their own research questions
Who should attend:
All faculty, researchers, and affiliated staff at Brown, URI, and the affiliated hospital systems who are interested in team-based science approaches. Physician scientists and junior faculty are encouraged to attend.
The Warren Alpert Medical School of Brown University is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physicians: The Warren Alpert Medical School of Brown University designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Mar512:00pm - 1:30pm70 Ship Street
Presented by the Research Design, Epidemiology, and Biostatistics Core of Advance-CTR, this bi-monthly Seminar Series offers instruction on data analysis (first Tuesday of each month), and study design (last Thursday of each month). The Seminars are available to attend in-person, or remotely via Zoom.
Jess Kaminsky & Gabriella Silva: “Exploratory Data Analysis”
Types of variables, summary statistics, measures of center, basic graphs (boxplots, histograms, etc).
Mar54:00pmSciences Library, Science Center, 3rd Floor
SAVE THE DATE!
The Science Center is excited to announce that on March 5th at 4 pm in the Main room #315, we will be hosting the ultimate ~psychedelic~ experience! Trip up your taste buds with taste berries after a short introduction by Neuroscience faculty member Dr. John Stein.
Mar611:00am - 12:30pmButler Campus
Brain & Cognitive Health in a Sociocultural Framework
Monica Rivera Mindt, Ph.D., A.B.P.P.
President, Hispanic Neuropsychological Society (HNS)
Board Certified in Clinical Neuropsychology
Professor of Psychology & Latin American Latino Studies Institute
Fordham University, Department of Neurology
Icahn School of Medicine at Mount Sinai
Wednesday, March 6, 2019
Butler Hospital ◊ Ray Hall Conference Center ◊ 11:00 am - 12:30 pm
Mar65:30pm - 7:00pmCogut Institute, Pembroke Hall
Complexity and uncertainty are common features of our everyday lives. However, we tend to do everything we can to minimize their presence and effect. This effort operates at the small, transactional scale (e.g., handrails on stairs) as well as large and systemic (e.g., how we organize and structure knowledge). As such, the achievement of expertise within a discipline can also be misunderstood to be the elimination of uncertainty. But what if, in order to articulate and realize new futures with better outcomes, a practitioner needs to have a productive relationship with complexity and uncertainty? This dynamic characterizes creative practices, especially design, and is part of the reason why design has relevance today in unexpected places. In this talk, Justin W. Cook, Director for the Center for Complexity at RISD, explores what can be gained by introducing what appears to be inefficiency, lack of expertise, and increased sources of risk into clinical decision-making and argues for a greater balance between the evidence-based clinical practice and a practice of uncertainty.
Justin Cook is a faculty member and Provost Fellow at RISD where he works to advance strategic design and its capacity to be transformative. He works with research teams at MIT and Harvard, and is Senior Lead for Strategy at the Finnish Innovation Fund, Sitra, advising project teams on impact investing, internationalization, and urban development.
This event is part of the Creative Medicine Series which is co-sponsored by the Department of Emergency Medicine.
Mar158:00am - 12:00pm121 South Main Street
Presented by the Clinical Research Design, Epidemiology, and Biostatistics Core of Advance-CTR
What is evidence-based medicine, and how do we sort and evaluate available evidence to support decision-makers?
In this half-day course, experts from Brown’s School of Public Health will discuss:
- The role and value of systematic reviews, the basic steps involved in conducting a systematic review, and how they can be applied to public health and health policy;
- The major principles and techniques of statistical analysis of meta-analytic data with a focus on summary data from reports and individual data from studies; and
- Meta-analysis in the context of evidence-based science, with discussion around the basic principles of network meta-analysis and the validity of its assumptions, including the key role that potential effect modifiers play.
Brown University research librarians will also discuss the resources and support available to clinical and academic faculty who would like to conduct a systematic review.
Participants will gain an increased awareness and knowledge of how systematic reviews can:
- Enable better choice of or recommendation of treatments; and
- Lead to more accurate diagnosis.
The Warren Alpert Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physicians: The Warren Alpert Medical School of Brown University designates this live activity for a maximum of 3.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- Other Healthcare Professionals: Participants will receive a Certificate of Attendance stating this program is designated for 3.5 hours AMA PRA Category 1 Credits™. This credit is accepted by the AAPA and AANP.
- Kristin Danko, PhD, Postdoctoral Research Associate in Health Services, Policy and Practice at the Brown University School of Public Health
- Ian Saldanha, MD, MPH, Assistant Professor of Health Services, Policy and Practice, Assistant Professor of Epidemiology at the Brown University School of Public Health
- Christopher Schmid, PhD, Professor of Biostatistics, Chair of Biostatistics at the Brown University School of Public Health
Details: This course is free but registration is required as space is limited. Register now using the link above.
Mar1710:00amEngineering Research Center
To culminate Brain Awareness Week, the Carney Institute for Brain Science, Brown Brain Bee, and Cure Alliance for Mental Illness present the fourth annual Brown Brain Fair! The Brain Fair will feature a wide range of interactive demonstrations that will educate audiences of all ages about the mind and brain. Adults can enjoy fun and accessible exhibitions about ongoing research at Brown, and children can participate in art projects, games and face painting.
Mar2611:00am - 3:00pmBrown Campus
EVENT SCHEDULE, Tuesday, March 26th
Keynote Address: Begins promptly at 1:00 pm, Salomon Hall
Poster Session: 11:00 am—12:45 pm
Lunch: Available from 11:30 am—12:45 pm at Sayles Hall
YOU MUST RSVP TO RESERVE A LUNCH (even if you submitted a poster)
Poster Awards: After keynote address
Mar271:00pm - 2:00pmRhode Island Hospital