LCDS Seminar

Monday, February 25, 2019
4:00pm
Room 108, 170 Hope Street

Thomas Michael, Harvard

Title: Bridging time and length scales in filamentous protein self-assembly

Abstract: Filamentous protein self-assembly is a process in which dispersed proteins assemble spontaneously to form ordered elongated structures. This phenomenon is an essential characteristic of life, finds widespread use in numerous nanotechnological applications, but is also at the heart of pathologies of many types, including Parkinson’s and Alzheimer’s diseases. To exploit protein self-assembly for nanotechnology or curtail it for medical purposes it is necessary to quantify the fundamental principles that control the way dispersed molecules assemble into these ordered structures. The fundamental challenge in establishing such an understanding in a rigorous manner is the disparate nature of the spatial and temporal scales involved. In this talk, I demonstrate how we can address this challenge by bringing the power of physical methods to protein self-assembly to connect microscopic mechanisms with macroscopic observations of such phenomena. In a first part of the talk, I discuss a unified theory of the kinetics of filamentous protein assembly and show how these results reveal simple rate laws that provide the basis for interpreting experimental data in terms of specific mechanisms controlling the proliferation of fibrils. I will then discuss how the resulting methods can guide us in the development of rational strategies for controlling aberrant protein aggregation in time and space. I will bring together protein aggregation kinetics with optimal control theory to determine explicit optimal administration protocols of drugs that inhibit specific molecular events during the aggregation process. I will also introduce ideas from liquid-liquid phase separation to investigate how liquid cellular compartments could be implicated in spatially regulating protein aggregation.

The Office of the Vice President for Research is conducting this training workshop designed to assist in effectively disseminating scientific knowledge to a broad audience. Developed specifically for Brown faculty in the life and physical sciences, the workshop will feature media training and panel discussions by professionals at and beyond Brown with expertise in communicating with the general public and government officials.

Overview and Media Training

• 12:00 to 12:45 Lunch and Remarks from Jill Pipher: Why this, Why now?
• 12:45 to 2:15 Media Training 201: Effectively Amplifying Your Research

Panel Discussions

• 2:30 to 3:30 Communications: Translating Science for a General Audience
• 3:30 to 4:30 Government Relations: Making the Case for Science to Government Officials

Reception

• 4:30 to 6:00 Informal discussion and Reception

Space is limited! Remember, please RSVP  to secure your seat.

Participants may register for part of the day or the full conference.

Title: “Delirium and Dementia

Speaker: Michael Reznik, MD, Assistant Professor The Warren Alpert Medical School, Department of Neurology, Rhode Island Hospital

Time: 1:00PM - 2:00PM

Location: Ambulatory Patient Center (APC Building), Leone Conference Room 133,

Rhode Island Hospital

Carney Innovations Awards

Robert J. & Nancy D. Carney Institute for Brain Science Lunch Talk

Thursday, February 28

12 - 1:30 p.m.

Sharpe Refectory, Chancellor’s Dining Room

 

Learn more about the Innovation Awards program and hear from some recipients of prior awards.

Register now for, “Better Together: Putting Team Science Theory into Practice to Enhance Your Research,” a workshop presented by Debbie Cornman, PhD, and Katie Sharkey, MD, PhD. 

Medical research continues to move away from the traditional “independent investigator” model, and toward collaborative approaches that integrate diverse disciplines with traditional biomedical sciences.

The National Institutes of Health established team science approaches as a major goal in its 2003 Roadmap . Yet, despite educational efforts and funding incentives, barriers toward achieving this goal remain. Many investigators are not aware of how to implement team science approaches into their research, or utilize available support.

In this workshop, Debbie Cornman, PhD and Katie Sharkey, MD, PhD will discuss the latest findings in the “science of team science,” and teach investigators how to implement strategies and techniques for successful team science approaches into their own research.

By the conclusion of the workshop, attendees will:

• Discuss the theories behind a team science approach
• Appraise their own readiness for engaging in team science
• Apply the team science approach to their own research questions

Who should attend:

All faculty, researchers, and affiliated staff at Brown, URI, and the affiliated hospital systems who are interested in team-based science approaches. Physician scientists and junior faculty are encouraged to attend.

Accreditation:

The Warren Alpert Medical School of Brown University is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit designation:

Physicians: The Warren Alpert Medical School of Brown University designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Learn about the presenters . 

Presented by the Research Design, Epidemiology, and Biostatistics Core of Advance-CTR, this bi-monthly Seminar Series offers instruction on data analysis (first Tuesday of each month), and study design (last Thursday of each month). The Seminars are available to attend in-person, or remotely via Zoom.

Jess Kaminsky & Gabriella Silva: “Exploratory Data Analysis”

Types of variables, summary statistics, measures of center, basic graphs (boxplots, histograms, etc).

Register to watch remotely .

Brain & Cognitive Health in a Sociocultural Framework

Monica Rivera Mindt, Ph.D., A.B.P.P.

President, Hispanic Neuropsychological Society (HNS)

Board Certified in Clinical Neuropsychology

Professor of Psychology & Latin American Latino Studies Institute

Fordham University, Department of Neurology

Icahn School of Medicine at Mount Sinai

Wednesday, March 6, 2019
Butler Hospital ◊ Ray Hall Conference Center ◊ 11:00 am - 12:30 pm

Presented by the Clinical Research Design, Epidemiology, and Biostatistics Core of Advance-CTR

What is evidence-based medicine, and how do we sort and evaluate available evidence to support decision-makers?

In this half-day course, experts from Brown’s School of Public Health will discuss:

• The role and value of systematic reviews, the basic steps involved in conducting a systematic review, and how they can be applied to public health and health policy;
• The major principles and techniques of statistical analysis of meta-analytic data with a focus on summary data from reports and individual data from studies; and
• Meta-analysis in the context of evidence-based science, with discussion around the basic principles of network meta-analysis and the validity of its assumptions, including the key role that potential effect modifiers play.

Brown University research librarians will also discuss the resources and support available to clinical and academic faculty who would like to conduct a systematic review.

Participants will gain an increased awareness and knowledge of how systematic reviews can:

• Enable better choice of or recommendation of treatments; and
• Lead to more accurate diagnosis.

Accreditation:

The Warren Alpert Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation:

• Physicians: The Warren Alpert Medical School of Brown University designates this live activity for a maximum of 3.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

• Other Healthcare Professionals: Participants will receive a Certificate of Attendance stating this program is designated for 3.5 hours AMA PRA Category 1 Credits™. This credit is accepted by the AAPA and AANP.

Featuring:

• Kristin Danko, PhD, Postdoctoral Research Associate in Health Services, Policy and Practice at the Brown University School of Public Health
• Ian Saldanha, MD, MPH, Assistant Professor of Health Services, Policy and Practice, Assistant Professor of Epidemiology at the Brown University School of Public Health
• Christopher Schmid, PhD, Professor of Biostatistics, Chair of Biostatistics at the Brown University School of Public Health

Details: This course is free but registration is required as space is limited. Register now using the link above. 

EVENT SCHEDULE, Tuesday, March 26th

Keynote Address: Begins promptly at 1:00 pm, Salomon Hall

Poster Session: 11:00 am—12:45 pm

Lunch: Available from 11:30 am—12:45 pm at Sayles Hall

YOU MUST RSVP TO RESERVE A LUNCH (even if you submitted a poster)

Poster Awards: After keynote address