Neurobiology of Cells and Circuits

This research theme nucleates faculty teams from multiple departments to advance our understanding of the function of neural circuits, building on a foundation of genetic, molecular, and cellular approaches. With a transformative $25M gift, we established the Center for the Neurobiology of Cells and Circuits to coalesce work in this area, including investigating the causes of autism spectrum disorders, teasing apart the molecules, cells, and circuits underlying addiction and reward, and creating a novel technology to map neural circuits.

Research Projects

Advanced systems methods applied to understanding and treating cerebrospinal fluid disorders

Cognition and Behavior, Computational Brain Science, Neurobiology of Cells & Circuits, Neuroengineering and Neurotechnology

Brain networks: Inferring cortical microcircuitry with electrophysiology

Computational Brain Science, Neurobiology of Cells & Circuits

Computational methods for faster, more accurate, and more versatile segmentation software for serial electron-microscopic analysis

Computational Brain Science, Neurobiology of Cells & Circuits, Neuroengineering and Neurotechnology

Developing novel cognitive and neuroimaging markers of preclinical Alzheimer’s disease

Alzheimer’s Disease, Cognition and Behavior, Neurobiology of Cells & Circuits

Discovering the mechanisms underlying brain aging using direct reprogramming

Alzheimer’s Disease, Neurobiology of Cells & Circuits

Human Neocortical Neurosolver for circuit-level interpretation of human MEG/EEG

BRAINSTORM, Cognition and Behavior, Computational Brain Science, Neurobiology of Cells & Circuits

Movement disorders: Rational design of deep brain stimulation with human electrophysiology and computational neural modeling

Cognition and Behavior, Computational Brain Science, Neurobiology of Cells & Circuits, Neuroengineering and Neurotechnology

New biomarkers for neurodegenerative disease

Alzheimer’s Disease, Neurobiology of Cells & Circuits

Precision TMS: Using EEG and machine learning to predict TMS response

BRAINSTORM, Computational Brain Science, Neurobiology of Cells & Circuits

Rational design of brain stimulation for neurological and psychiatric disorders

BRAINSTORM, Cognition and Behavior, Computational Brain Science, Neurobiology of Cells & Circuits

Retinal imaging: The eye as a window to the brain

Cognition and Behavior, Neurobiology of Cells & Circuits

Targeting age-related inflammation to slow Alzheimer’s disease: The LINE-AD study

Alzheimer’s Disease, Cognition and Behavior, Neurobiology of Cells & Circuits

The role of Microfibrillar Associated Protein 2 and Notch1 in alcohol cravings

Cognition and Behavior, Neurobiology of Cells & Circuits

Understanding contributions of alternative splicing to appetitive memory

Cognition and Behavior, Neurobiology of Cells & Circuits